17-trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F2α
Molecular Weight:
458.5
Molecular Formula:
C24H33O5F3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
A lot of 17-phenyl trinor prostaglandin F2α (17-phenyl trinor PGF2α) derivatives have been approved for treatment of glaucoma(1,2,3). The ones where the 13,14-double bond has been hydrogenated retain good potency, but show a significantly reduced incidence of local irritant side effects(4). 17-trifluoromethylphenyl-13,14-dihydro trinor PGF2α bears an aromatic ring which is reminiscent of the trifluoromethyl-phenoxy ring of travoprost ((+)-fluprostenol isopropyl ester). As an ocular hypotensive agent, it would be expected that 17-trifluoromethylphenyl-13,14-dihydro trinor PGF2α would act like the free acid of latanoprost.
17-trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F2α References
- From PGF(2alpha)-isopropyl ester to latanoprost: a review of the development of xalatan: the Proctor Lecture. | Stjernschantz, JW. 2001. Invest Ophthalmol Vis Sci. 42: 1134-45. PMID: 11328719
- The pharmacology of bimatoprost (Lumigan). | Woodward, DF., et al. 2001. Surv Ophthalmol. 45 Suppl 4: S337-45. PMID: 11434936
- Phenyl-substituted prostaglandins: potent and selective antiglaucoma agents. | Resul, B., et al. 1993. J Med Chem. 36: 243-8. PMID: 8423596
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
17-trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F2α, 1 mg | sc-223182 | 1 mg | $66.00 | |||
17-trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F2α, 5 mg | sc-223182A | 5 mg | $300.00 |