Molecular structure of 17(R)-HDoHE, CAS Number: 155976-53-7
17(R)-HDoHE (CAS 155976-53-7)
Alternate Names:
17(R)-hydroxy Docosahexaenoic Acid
Application:
17(R)-HDoHE is the main oxidation product of DHA
CAS Number:
155976-53-7
Molecular Weight:
344.49
Molecular Formula:
C22H32O3
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Resolvins are a group of polyhydroxylated metabolites of docosahexaenoic acid (DHA) found in the inflammatory exudates of aspirin-treated experimental animals.1 17(R)-HDoHE is the primary oxygenation product of DHA when exposed to aspirin-inhibited cyclooxygenase-2, whereit serves as a precursor to resolvins and has intrinsic biological activity, such as the inhibition of TNFα-induced IL-1β expression in human glioma cells.1
17(R)-HDoHE (CAS 155976-53-7) References
- Resolvins: a family of bioactive products of omega-3 fatty acid transformation circuits initiated by aspirin treatment that counter proinflammation signals. | Serhan, CN., et al. 2002. J Exp Med. 196: 1025-37. PMID: 12391014
- The precursor of resolvin D series and aspirin-triggered resolvin D1 display anti-hyperalgesic properties in adjuvant-induced arthritis in rats. | Lima-Garcia, JF., et al. 2011. Br J Pharmacol. 164: 278-93. PMID: 21418187
- Resolvins are potent analgesics for arthritic pain. | Xu, ZZ. and Ji, RR. 2011. Br J Pharmacol. 164: 274-7. PMID: 21418190
- Specialized proresolving mediators enhance human B cell differentiation to antibody-secreting cells. | Ramon, S., et al. 2012. J Immunol. 189: 1036-42. PMID: 22711890
- Lipid and lipid mediator profiling of human synovial fluid in rheumatoid arthritis patients by means of LC-MS/MS. | Giera, M., et al. 2012. Biochim Biophys Acta. 1821: 1415-24. PMID: 22841830
- Resolvins: Endogenously-Generated Potent Painkilling Substances and their Therapeutic Perspectives. | Yoo, S., et al. 2013. Curr Neuropharmacol. 11: 664-76. PMID: 24396341
- Targeting the D Series Resolvin Receptor System for the Treatment of Osteoarthritis Pain. | Huang, J., et al. 2017. Arthritis Rheumatol. 69: 996-1008. PMID: 27860453
- Local and systemic inflammatory lipid profiling in a rat model of osteoarthritis with metabolic dysregulation. | de Visser, HM., et al. 2018. PLoS One. 13: e0196308. PMID: 29684084
- Impact of a weight loss and fitness intervention on exercise-associated plasma oxylipin patterns in obese, insulin-resistant, sedentary women. | Grapov, D., et al. 2020. Physiol Rep. 8: e14547. PMID: 32869956
- Specialized Pro-Resolving Mediators as Resolution Pharmacology for the Control of Pain and Itch. | Ji, RR. 2023. Annu Rev Pharmacol Toxicol. 63: 273-293. PMID: 36100219
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
17(R)-HDoHE, 25 µg | sc-205063 | 25 µg | $184.00 | |||
17(R)-HDoHE, 50 µg | sc-205063A | 50 µg | $350.00 |