Molecular structure of 17-Phenyl-trinor-prostaglandin E2, CAS Number: 38315-43-4
17-Phenyl-trinor-prostaglandin E2 (CAS 38315-43-4)
See product citations (5)
Alternate Names:
7-[3-hydroxy-2-(3-hydroxy-5-phenylpent-1-en-1-yl)-5-oxocyclopentyl]hept-5-enoic acid
Application:
17-Phenyl-trinor-prostaglandin E2 is a synthetic analog of PGE2 found to be a selective EP1 and EP3 receptor agonist
CAS Number:
38315-43-4
Purity:
98%
Molecular Weight:
386.48
Molecular Formula:
C23H30O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
17-Phenyl-trinor-prostaglandin E2 is a synthetic analog of prostaglandin E2 (PGE2 sc-201225), that was found to be a selective EP1 and EP3 receptor agonist, unlike PGE2 which antagonizes a variety of EP receptors. 17-Phenyl-trinor-prostaglandin E2 may act to cause contraction of the guinea pig ileum at a concentration of 11 muM, and is slightly less potent than PGE2 in stimulating gerbil colon and rat uterus. 17-Phenyl-trinor-prostaglandin E2 has an ED50 value of 350 mug/kg, and is 4.4 times more potent than PGE2 as an antifertility agent in hamsters.
17-Phenyl-trinor-prostaglandin E,[object Object], (CAS 38315-43-4) References
- Bovine iris-sphincter muscle lacks FP receptor binding sites. | Bhattacherjee, P., et al. 1999. Ocul Immunol Inflamm. 7: 39-50. PMID: 10410874
- Effect of prostaglandin E(2) on the proliferation, Ca(2+) mobilization and cAMP in HT-29 human colon adenocarcinoma cells. | Cassano, G., et al. 2000. Cancer Lett. 152: 217-22. PMID: 10773415
- Prostaglandin E(2) enhances axonal transport and neuritogenesis in cultured mouse dorsal root ganglion neurons. | Hiruma, H., et al. 2000. Neuroscience. 100: 885-91. PMID: 11036222
- Direct activation of rat spinal dorsal horn neurons by prostaglandin E2. | Baba, H., et al. 2001. J Neurosci. 21: 1750-6. PMID: 11222664
- Prostaglandin E(2) induces caspase-dependent apoptosis in rat cortical cells. | Takadera, T., et al. 2002. Neurosci Lett. 317: 61-4. PMID: 11755240
- Prostanoid-induced relaxation of precontracted cat ciliary muscle is mediated by EP2 and DP receptors. | Chen, J. and Woodward, DF. 1992. Invest Ophthalmol Vis Sci. 33: 3195-201. PMID: 1328113
- Prostaglandin E2 induced caspase-dependent apoptosis possibly through activation of EP2 receptors in cultured hippocampal neurons. | Takadera, T., et al. 2004. Neurochem Int. 45: 713-9. PMID: 15234114
- Characterization of receptors involved in the direct and indirect actions of prostaglandins E and I on the guinea-pig ileum. | Lawrence, RA., et al. 1992. Br J Pharmacol. 105: 271-8. PMID: 1559125
- Prostaglandin E2 reduces amyloid beta-induced phagocytosis in cultured rat microglia. | Nagano, T., et al. 2010. Brain Res. 1323: 11-7. PMID: 20144888
- Prostaglandin E2 increases migration and proliferation of human glioblastoma cells by activating transient receptor potential melastatin 7 channels. | Tian, Y., et al. 2018. J Cell Mol Med. 22: 6327-6337. PMID: 30338939
- Structure-activity studies of configurationally rigid arylprostaglandins. | Schaaf, TK., et al. 1983. J Med Chem. 26: 328-34. PMID: 6827554
- Pharmacological characterization in vitro of prostanoid receptors in the myometrium of nonpregnant ewes. | Crankshaw, DJ. and Gaspar, V. 1995. J Reprod Fertil. 103: 55-61. PMID: 7535849
- Biological activities of 17-phenyl-18,19,20-trinorprostaglandins. | Miller, WL., et al. 1975. Prostaglandins. 9: 9-18. PMID: 806103
Activator of:
EP1, and EP3.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
17-Phenyl-trinor-prostaglandin E2, 1 mg | sc-201255 | 1 mg | $74.00 | |||
17-Phenyl-trinor-prostaglandin E2, 10 mg | sc-201255A | 10 mg | $599.00 |