17-keto-(4Z,7Z,10Z,13Z,15E,19Z)-Docosahexaenoic Acid (CAS 1233715-28-0)

17-keto-(4Z,7Z,10Z,13Z,15E,19Z)-Docosahexaenoic Acid (DHA) is a chemically modified form of docosahexaenoic acid, a polyunsaturated omega-3 fatty acid that is critical for maintaining the structural integrity of cellular membranes, particularly in neural and retinal tissues. The modification in this derivative includes the addition of a keto group at the 17th carbon, altering its chemical and biological properties. This specific structural alteration has made 17-keto-DHA a focal point in biochemical research, particularly in studies centered on the oxidative pathways of fatty acids and their role in cellular signaling mechanisms. The presence of multiple double bonds along with the keto group affects how this molecule interacts within cellular environments, influencing the fluidity and functionality of cell membranes. Researchers utilize this compound to investigate the potential signaling capabilities of oxidized DHA derivatives, examining how such modifications impact cellular communication pathways, including those involved in the regulation of inflammatory responses and cellular defense mechanisms. As a research tool, 17-keto-DHA helps in understanding the complex dynamics of lipid peroxidation products in biological systems, providing insights into the stability and activity of oxidized lipids. This contributes to a broader comprehension of lipid-mediated signaling in cell physiology and pathophysiology.