Molecular structure of 17-Amino Geldanamycin, CAS Number: 64202-81-9
17-Amino Geldanamycin (CAS 64202-81-9)
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Alternate Names:
17-Aminogeldanamycin
Application:
17-Amino Geldanamycin is an active metabolite of 17AAG
CAS Number:
64202-81-9
Molecular Weight:
545.62
Molecular Formula:
C28H39N3O8
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
The active metabolite of 17-(Allylamino)geldanamycin (17AAG).
17-Amino Geldanamycin (CAS 64202-81-9) References
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- A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors. | Kamal, A., et al. 2003. Nature. 425: 407-10. PMID: 14508491
- Phase I trial of 17-allylamino-17-demethoxygeldanamycin in patients with advanced cancer. | Goetz, MP., et al. 2005. J Clin Oncol. 23: 1078-87. PMID: 15718306
- Highlights in experimental therapeutics. | Burger, AM. 2007. Cancer Lett. 245: 11-21. PMID: 16647200
- Phase I pharmacokinetic and pharmacodynamic study of 17-N-allylamino-17-demethoxygeldanamycin in pediatric patients with recurrent or refractory solid tumors: a pediatric oncology experimental therapeutics investigators consortium study. | Bagatell, R., et al. 2007. Clin Cancer Res. 13: 1783-8. PMID: 17363533
- A limited sample model to predict area under the drug concentration curve for 17-(allylamino)-17-demethoxygeldanamycin and its active metabolite 17-(amino)-17-demethoxygeldanomycin. | Furth, AF., et al. 2008. Cancer Chemother Pharmacol. 61: 39-45. PMID: 17909811
- Novel immunoconjugates comprised of streptonigrin and 17-amino-geldanamycin attached via a dipeptide-p-aminobenzyl-amine linker system. | Burke, PJ., et al. 2009. Bioorg Med Chem Lett. 19: 2650-3. PMID: 19386499
- Tanespimycin: the opportunities and challenges of targeting heat shock protein 90. | Erlichman, C. 2009. Expert Opin Investig Drugs. 18: 861-8. PMID: 19466875
- Discovery and development of heat shock protein 90 inhibitors as anticancer agents: a review of patented potent geldanamycin derivatives. | Kim, T., et al. 2013. Expert Opin Ther Pat. 23: 919-43. PMID: 23641970
- Synthesis and preliminary evaluation steroidal antiestrogen-geldanamycin conjugates. | Adam Hendricks, J., et al. 2013. Bioorg Med Chem Lett. 23: 3635-9. PMID: 23648180
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
17-Amino Geldanamycin, 1 mg | sc-206283 | 1 mg | $430.00 |