Date published: 2026-4-24

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17(18)-EpETE

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Alternate Names:
(±)17,18-epoxy-5Z,8Z,11Z,14Z-eicosatetraenoic acid
Application:
17(18)-EpETE is a part of the epoxygenase pathway
Molecular Weight:
318.5
Molecular Formula:
C20H30O3
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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17(18)-EpETE, associated with the CAS number provided, is a specific epoxy derivative of eicosapentaenoic acid (EPA), an omega-3 fatty acid primarily found in marine oils. This compound is produced enzymatically through the action of cytochrome P450 epoxygenases on EPA. As an epoxyeicosatetraenoic acid, 17(18)-EpETE plays a significant role in modulating various biological processes through its interactions with cellular signaling pathways. The compound influences a range of cellular functions, including the modulation of inflammatory responses and the regulation of blood flow, primarily due to its effects on vascular endothelial cells. In research, 17(18)-EpETE is utilized to explore mechanisms related to cellular signaling that contribute to maintaining homeostasis and responding to environmental stressors. Studies often focus on its role in affecting the endothelial-derived factors that regulate vasodilation and vasoconstriction, crucial for understanding vascular health. Additionally, its impact on inflammatory mediators provides insights into how lipid metabolites can influence immune responses at a cellular level. By examining these interactions, researchers can better understand the complex network of lipid-mediated signaling that supports cellular function and adaptation in various physiological and stress-related contexts.


17(18)-EpETE References

  1. Biosynthesis of prostaglandins from 17(18)epoxy-eicosatetraenoic acid, a cytochrome P-450 metabolite of eicosapentaenoic acid.  |  Oliw, EH., et al. 1992. Biochim Biophys Acta. 1126: 261-8. PMID: 1637854
  2. Eicosapentaenoic acid is converted via ω-3 epoxygenation to the anti-inflammatory metabolite 12-hydroxy-17,18-epoxyeicosatetraenoic acid.  |  Kubota, T., et al. 2014. FASEB J. 28: 586-93. PMID: 24128889
  3. MAG-EPA and 17,18-EpETE target cytoplasmic signalling pathways to reduce short-term airway hyperresponsiveness.  |  Khaddaj-Mallat, R. and Rousseau, É. 2015. Pflugers Arch. 467: 1591-1605. PMID: 25113382
  4. The 17,18-epoxyeicosatetraenoic acid-G protein-coupled receptor 40 axis ameliorates contact hypersensitivity by inhibiting neutrophil mobility in mice and cynomolgus macaques.  |  Nagatake, T., et al. 2018. J Allergy Clin Immunol. 142: 470-484.e12. PMID: 29288079
  5. Comprehensive analysis of the mouse cytochrome P450 family responsible for omega-3 epoxidation of eicosapentaenoic acid.  |  Isobe, Y., et al. 2018. Sci Rep. 8: 7954. PMID: 29784972
  6. 17(S),18(R)-epoxyeicosatetraenoic acid generated by cytochrome P450 BM-3 from Bacillus megaterium inhibits the development of contact hypersensitivity via G-protein-coupled receptor 40-mediated neutrophil suppression.  |  Saika, A., et al. 2020. FASEB Bioadv. 2: 59-71. PMID: 32123857
  7. Numb is required for optimal contraction of skeletal muscle.  |  De Gasperi, R., et al. 2022. J Cachexia Sarcopenia Muscle. 13: 454-466. PMID: 35001540
  8. Cytochrome P450 epoxygenase-derived EPA and DHA oxylipins 17,18-epoxyeicosatetraenoic acid and 19,20-epoxydocosapentaenoic acid promote BAT thermogenesis and WAT browning through the GPR120-AMPKα signaling pathway.  |  Yang, X., et al. 2022. Food Funct. 13: 1232-1245. PMID: 35019933
  9. Genetic deletion of Cyp4f18 disrupts the omega-3 epoxidation pathway and results in psoriasis-like dermatitis.  |  Yoshida, M., et al. 2022. FASEB J. 36: e22648. PMID: 36374250

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

17(18)-EpETE, 25 µg

sc-220653
25 µg
$78.00

17(18)-EpETE, 50 µg

sc-220653A
50 µg
$147.00