16α-Methyl Prednisolone (CAS 10417-63-7)

16α-Methyl Prednisolone is a synthetic analog of prednisolone, distinguished by a methyl group at the 16α position, which confers enhanced anti-inflammatory and immunosuppressive properties. This modification not only increases its potency but also reduces the mineralocorticoid effects, making it particularly useful in research applications where a strong glucocorticoid response is desired without the accompanying sodium retention and hypertension often seen with natural glucocorticoids. In experimental models, it serves as a tool for elucidating the pathways through which glucocorticoids modulate immune responses and inflammation. By binding to glucocorticoid receptors, it influences the transcription of genes involved in the inflammatory process, offering insights into the mechanism of action of glucocorticoids and their role in immune regulation. Its application in research extends to studying its effects on various cell types and signaling pathways, providing a deeper understanding of its potential mechanistic roles in modulating inflammation and immune function at a molecular level.