Date published: 2025-12-5

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16-Mercaptohexadecanoic acid (CAS 69839-68-5)

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Alternate Names:
MHDA
Application:
16-Mercaptohexadecanoic acid is a carboxylic acid used to form carboxylic anhydrides on self-assembled monolayers with Fluoro N,N,N′,N′-tetramethylforamidinium hexafluorophosphate
CAS Number:
69839-68-5
Purity:
≥90%
Molecular Weight:
288.49
Molecular Formula:
C16H32O2S
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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16-Mercaptohexadecanoic acid is utilized for its capacity to form self-assembled monolayers on gold, aiding in the creation of biosensors and nanoelectronic devices. Furthermore, it is integral to the study of enzyme kinetics and cellular signaling due to its interaction with proteins and enzymes, including cytochrome P450 enzymes involved in metabolic pathways, and adenylyl cyclase, which has a regulatory role in cell signaling. Additionally, its binding to fatty acid-binding proteins, which are key in fatty acid transport and metabolism, is of significant interest in research focused on understanding biological mechanisms at the molecular level.


16-Mercaptohexadecanoic acid (CAS 69839-68-5) References

  1. Spreading of 16-mercaptohexadecanoic acid in microcontact printing.  |  Sharpe, RB., et al. 2004. Langmuir. 20: 8646-51. PMID: 15379487
  2. Reduction of nonspecific protein binding on surface plasmon resonance biosensors.  |  Masson, JF., et al. 2006. Anal Bioanal Chem. 386: 1951-9. PMID: 17086391
  3. Improvements in the characterization of the crystalline structure of acid-terminated alkanethiol self-assembled monolayers on Au(111).  |  Mendoza, SM., et al. 2007. Langmuir. 23: 582-8. PMID: 17209609
  4. Determination of the optimized conditions for coupling oligonucleotides with 16-mercaptohexadecanoic acid chemically adsorbed upon Au.  |  Wu, YT., et al. 2007. Bioconjug Chem. 18: 1897-904. PMID: 17970584
  5. Sensitive detection of clozapine using a gold electrode modified with 16-mercaptohexadecanoic acid self-assembled monolayer.  |  Huang, F., et al. 2007. Talanta. 72: 457-62. PMID: 19071640
  6. Biocompatible Gold Nanorod Conjugates for Preclinical Biomedical Research.  |  Liopo, A., et al. 2012. J Nanomed Nanotechnol. S2: PMID: 23264890
  7. Isolation of carboxylic acid-protected Au25 clusters using a borohydride purification strategy.  |  Shivhare, A., et al. 2015. Langmuir. 31: 1835-41. PMID: 25590767
  8. Design and preparation of quantum dots fluorescent probes for in situ identification of Microthrix parvicella in bulking sludge.  |  Fei, X., et al. 2016. Appl Microbiol Biotechnol. 100: 961-8. PMID: 26446385
  9. Photosensitizer-loaded gold nanorods for near infrared photodynamic and photothermal cancer therapy.  |  Bhana, S., et al. 2016. J Colloid Interface Sci. 469: 8-16. PMID: 26866884
  10. A Portable Impedance Immunosensing System for Rapid Detection of Salmonella Typhimurium.  |  Wen, T., et al. 2017. Sensors (Basel). 17: PMID: 28846643
  11. Formation Kinetics of Mixed Self-Assembled Monolayers of Alkanethiols on GaAs(100).  |  Lacour, V., et al. 2019. Langmuir. 35: 4415-4427. PMID: 29056049
  12. The influence of surface chemistry on the kinetics and thermodynamics of bacterial adhesion.  |  Oh, JK., et al. 2018. Sci Rep. 8: 17247. PMID: 30467352
  13. Heavy metals detection in river water with cantilever nanobiosensor.  |  Rigo, AA., et al. 2020. J Environ Sci Health B. 55: 239-249. PMID: 31680618
  14. Wettability Contrast in the Hexagonally Patterned Gold Substrate of Distinct Morphologies for Enhanced Fog Harvesting.  |  Malani S, B. and Viswanath, P. 2021. Langmuir. 37: 8281-8289. PMID: 34189916
  15. How to Use Localized Surface Plasmon for Monitoring the Adsorption of Thiol Molecules on Gold Nanoparticles?  |  Dileseigres, AS., et al. 2022. Nanomaterials (Basel). 12: PMID: 35055309

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

16-Mercaptohexadecanoic acid, 1 g

sc-251623
1 g
$170.00

16-Mercaptohexadecanoic acid, 5 g

sc-251623A
5 g
$514.00