Molecular structure of 16,16-Dimethyl-prostaglandin E2, CAS Number: 39746-25-3
16,16-Dimethyl-prostaglandin E2 (CAS 39746-25-3)
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Alternate Names:
16,16-Dimethyl-prostaglandin E2 also known as 9-OXO-11ALPHA; 15R-DIHYDROXY-16,16-DIMETHYL-PROSTA-5Z,13E-DIEN-1-OIC ACID; (5z,11-alpha,13e,15r)-11, 15-dihydroxy-16,16-dimethyl-9-oxoprosta-5,13-dien-1; 15r)-13e;16,16-dimethyl-pge2; 5-heptenoicacid,7-(2-(4,4-dimethyl-3-hydroxy-1-octenyl)-3-hydroxy-5-oxocycl;opentyl)-;prosta-5,13-dien-1-oicacid,11,15-dihydroxy-16,16-dimethyl-9-oxo-,(5z,11-alph 16,16-dimethyl PGE2
Application:
16,16-Dimethyl-prostaglandin E2 is an antisecretory, antiulcer PGE2 analog that is resistant to metabolism
CAS Number:
39746-25-3
Purity:
≥98%
Molecular Weight:
380.52
Molecular Formula:
C22H36O5
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
16,16-Dimethyl-prostaglandin E2 is Prostaglandin E2 (PGE2 sc-201225) analog with potent cytoprotective activity that binds to PGDH (prostaglandin dehydrogenase or HPGD), but is resistant to metabolism, thereby inhibiting the enzyme. This enhanced resistance to metabolism imparts a higher duration of activity than Prostaglandin E2 (sc-201225), but the methylations do not severely affect the binding affinity for all four EP receptors (EP1, 2, 3, and 4). PGE2 is the most physiologically abundant eiconasoid regulating many biological functions and since this product has nearly identical binding affinities, 16,16-Dimethyl-prostaglandin E2 also has numerous and similar physiological functions. 16,16-Dimethyl-prostaglandin E2 is an inhibitor of PGDH and an activator of EP2.
16,16-Dimethyl-prostaglandin E,[object Object], (CAS 39746-25-3) References
- 16,16-Dimethyl prostaglandin E2 inhibits indomethacin-induced small intestinal lesions through EP3 and EP4 receptors. | Kunikata, T., et al. 2002. Dig Dis Sci. 47: 894-904. PMID: 11991626
- Subcutaneous or topical administration of 16,16 dimethyl prostaglandin E2 protects from radiation-induced alopecia in mice. | Hanson, WR., et al. 1992. Int J Radiat Oncol Biol Phys. 23: 333-7. PMID: 1587754
- Gastric antisecretory and antiulcer properties of PGE2, 15-methyl PGE2, and 16, 16-dimethyl PGE2. Intravenous, oral and intrajejunal administration. | Robert, A., et al. 1976. Gastroenterology. 70: 359-70. PMID: 174967
- 16,16-Dimethyl prostaglandin E2 efficacy on prevention and protection from bleomycin-induced lung injury and fibrosis. | Failla, M., et al. 2009. Am J Respir Cell Mol Biol. 41: 50-8. PMID: 19059888
- 16,16-Dimethyl prostaglandin E2 induces villus contraction in rats without affecting intestinal restitution. | Erickson, RA., et al. 1990. Gastroenterology. 99: 708-16. PMID: 2116342
- Studies on 15-hydroxyprostaglandin dehydrogenase with various prostaglandin analogues. | Ohno, H., et al. 1978. J Biochem. 84: 1485-94. PMID: 216666
- Treatment with 16,16'-dimethyl prostaglandin E2 before and after induction of colitis with trinitrobenzenesulfonic acid in rats decreases inflammation. | Allgayer, H., et al. 1989. Gastroenterology. 96: 1290-300. PMID: 2539306
- Early microcirculatory stasis in acute gastric mucosal injury in the rat and prevention by 16,16-dimethyl prostaglandin E2 or sodium thiosulfate. | Pihan, G., et al. 1986. Gastroenterology. 91: 1415-26. PMID: 2945748
- Gastric mucosal blood flow in rats after administration of 16,16-dimethyl prostaglandin E2 at a cytoprotective dose. | Leung, FW., et al. 1985. Gastroenterology. 88: 1948-53. PMID: 3873373
- Effect of 16,16-dimethyl prostaglandin E2 on the surface hydrophobicity of aspirin-treated canine gastric mucosa. | Lichtenberger, LM., et al. 1985. Gastroenterology. 88: 308-14. PMID: 3964778
- Effect of 16,16 dimethyl prostaglandin E2 on aspirin induced damage to rat gastric epithelial cells in tissue culture. | Terano, A., et al. 1984. Gut. 25: 19-25. PMID: 6197344
- Influence of long-term 16,16-dimethyl prostaglandin E2 treatment on the rat gastrointestinal mucosa. | Reinhart, WH., et al. 1983. Gastroenterology. 85: 1003-10. PMID: 6618097
- International Union of Pharmacology classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes. | Coleman, RA., et al. 1994. Pharmacol Rev. 46: 205-29. PMID: 7938166
- Identification of prostanoid receptors in rabbit non-pigmented ciliary epithelial cells. | Bhattacherjee, P., et al. 1996. Exp Eye Res. 62: 491-8. PMID: 8759517
Inhibitor of:
PGDH.Activator of:
EP2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
16,16-Dimethyl-prostaglandin E2, 1 mg | sc-201240 | 1 mg | $145.00 | |||
16,16-Dimethyl-prostaglandin E2, 5 mg | sc-201240B | 5 mg | $502.00 | |||
16,16-Dimethyl-prostaglandin E2, 10 mg | sc-201240A | 10 mg | $949.00 |