Molecular structure of 15(S)-HEPE, CAS Number: 86282-92-0
15(S)-HEPE (CAS 86282-92-0)
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Alternate Names:
15(S)-Hydroxyeicosa-5Z,8Z,11Z,13E,17Z-pentaenoic acid
Application:
15(S)-HEPE is an eicosapentaenoic acid-derived monohydroxy fatty acid
CAS Number:
86282-92-0
Purity:
≥98%
Molecular Weight:
318.5
Molecular Formula:
C20H30O3
Supplemental Information:
This is as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
15(S)-HEPE is a polyunsaturated fatty acid, that is a monohydroxy fatty acid synthesized from EPA by the action of 15-LO. The biosynthesis of 15-HEPE is from EPA in guinea pig epidermal enzyme preparations. This is generated by soybean lipoxygenation of EPA inhibits RBL-1 cell 5LO with an IC50=28µM.
15(S)-HEPE (CAS 86282-92-0) References
- 15-lipoxygenase metabolites of gamma-linolenic acid/eicosapentaenoic acid suppress growth and arachidonic acid metabolism in human prostatic adenocarcinoma cells: possible implications of dietary fatty acids. | Vang, K. and Ziboh, VA. 2005. Prostaglandins Leukot Essent Fatty Acids. 72: 363-72. PMID: 15850718
- 15S-lipoxygenase metabolism in the marine diatom Pseudo-nitzschia delicatissima. | D'Ippolito, G., et al. 2009. New Phytol. 183: 1064-1071. PMID: 19538551
- Guinea pig epidermis generates putative anti-inflammatory metabolites from fish oil polyunsaturated fatty acids. | Miller, C., et al. 1989. Lipids. 24: 998-1003. PMID: 2559281
- Drosophila Fed ARA and EPA Yields Eicosanoids, 15S-Hydroxy-5Z,8Z, 11Z, 13E-Eicosatetraenoic Acid, and 15S-Hydroxy-5Z,8Z,11Z,13E,17Z-Eicosapentaenoic Acid. | Tan, L., et al. 2016. Lipids. 51: 435-49. PMID: 26931457
- Derivatization enhanced separation and sensitivity of long chain-free fatty acids: Application to asthma using targeted and non-targeted liquid chromatography-mass spectrometry approach. | Bian, X., et al. 2017. Anal Chim Acta. 989: 59-70. PMID: 28915943
- n-3 Fatty Acid and Its Metabolite 18-HEPE Ameliorate Retinal Neuronal Cell Dysfunction by Enhancing Müller BDNF in Diabetic Retinopathy. | Suzumura, A., et al. 2020. Diabetes. 69: 724-735. PMID: 32029482
- Distinct Profiles of Specialized Pro-resolving Lipid Mediators and Corresponding Receptor Gene Expression in Periodontal Inflammation. | Ferguson, B., et al. 2020. Front Immunol. 11: 1307. PMID: 32670289
- Analysis of serum polyunsaturated fatty acid metabolites in allergic bronchopulmonary aspergillosis. | Li, L., et al. 2020. Respir Res. 21: 205. PMID: 32758241
- Human lipoxygenase isoforms form complex patterns of double and triple oxygenated compounds from eicosapentaenoic acid. | Kutzner, L., et al. 2020. Biochim Biophys Acta Mol Cell Biol Lipids. 1865: 158806. PMID: 32841762
- Subgingival Microbiome and Specialized Pro-Resolving Lipid Mediator Pathway Profiles Are Correlated in Periodontal Inflammation. | Lee, CT., et al. 2021. Front Immunol. 12: 691216. PMID: 34177951
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
15(S)-HEPE, 50 µg | sc-200951 | 50 µg | $78.00 |