15(R),19(R)-hydroxy Prostaglandin F1α
Molecular Weight:
372.5
Molecular Formula:
C20H36O6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
19(R)-Hydroxylated prostaglandins occur in µg/ml concentrations in the semen of some mammalian species, especially primates. In the case of humans, the compounds are primarily of the PGE series, and the hydroxyl stereochemistry is 15(S),19(R).1 19(R)-Hydroxylated prostaglandins are also found in the seminal plasma of marsupials, where F-type compounds of the 1 and 2-series predominate.2 The 15(R)-hydroxy epimer of these 19-hydroxylated prostaglandins is the inverse or "unnatural" isomer at C-15. The biological role of 19(R)-hydroxylated prostaglandins is not well established. In the F-series, 19(R)-hydroxylation is associated with a significant loss of receptor-mediated biological activity in some assays.3
15(R),19(R)-hydroxy Prostaglandin F1α References
1 Cooper, I., Kelly, R.W. The measurement of E and 19-hydroxy E prostaglandins in human seminal plasma. Prostaglandins 10 507-514 (1975). 2 Marley, P.B., Rodger, J.C., White, I.G., et al. 19-Hydroxylated prostaglandins in the semen of the marsupial Trichosurus vulpecula (brush-tailed possum). Comp Biochem Physiol 70B 619-621 (1981). 3 Woodward, D.F., Protzman, C.E., Krauss, A.H.P., et al. Identification of 19(R)-OH prostaglandin E2 as a selective prostanoid EP2-receptor agonist. Prostaglandins 46 371-383 (1993).Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
15(R),19(R)-hydroxy Prostaglandin F1α, 50 µg | sc-220631 | 50 µg | $48.00 | |||
15(R),19(R)-hydroxy Prostaglandin F1α, 100 µg | sc-220631A | 100 µg | $68.00 |