15(R)-17-phenyl trinor Prostaglandin F2α (CAS 41639-71-8)
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17-phenyl trinor Prostaglandin F2α N-ethyl amide (17-phenyl trinor PGF2α N-ethyl amide) is an F-series prostaglandin analog which has been approved for use as an ocular hypotensive drug, sold under the Allergan trade name Bimatoprost.1 Investigations have shown that Bimatoprost is converted by an amidase enzymatic activity in the human cornea to yield the corresponding free acid, with a conversion rate of about 25 µg/cornea/24 hours.2 The free acid, 17-phenyl trinor PGF2α, is a potent FP receptor agonist.3,4 15(R)-17-phenyl trinor PGF2α is the 15-epi, or "unnatural" isomer of this active free acid metabolite. It has much diminished FP receptor-mediated activity, which is generally 1.5 to 2 logs less than the 15(S)-isomer.5 In human and animal models of glaucoma, FP receptor agonist activity corresponds very closely with intraocular hypotensive activity.
15(R)-17-phenyl trinor Prostaglandin F2α (CAS 41639-71-8) References
- The pharmacology of bimatoprost (Lumigan). | Woodward, DF., et al. 2001. Surv Ophthalmol. 45 Suppl 4: S337-45. PMID: 11434936
- The hydrolysis of bimatoprost in corneal tissue generates a potent prostanoid FP receptor agonist. | Maxey, KM., et al. 2002. Surv Ophthalmol. 47 Suppl 1: S34-40. PMID: 12204699
- Cloning of the rat and human prostaglandin F2 alpha receptors and the expression of the rat prostaglandin F2 alpha receptor. | Lake, S., et al. 1994. FEBS Lett. 355: 317-25. PMID: 7988697
- Phenyl-substituted prostaglandins: potent and selective antiglaucoma agents. | Resul, B., et al. 1993. J Med Chem. 36: 243-8. PMID: 8423596
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
15(R)-17-phenyl trinor Prostaglandin F2α, 1 mg | sc-205030 | 1 mg | $60.00 | |||
15(R)-17-phenyl trinor Prostaglandin F2α, 5 mg | sc-205030A | 5 mg | $270.00 |