Molecular structure of 15(S)-HETrE, CAS Number: 92693-02-2
15(S)-HETrE (CAS 92693-02-2)
Alternate Names:
(8Z,11Z,13E,15S)-15-hydroxyicosa-8,11,13-trienoic acid
Application:
15(S)-HETrE is a 5-LO (5-lipoxygenase) inhibitor
CAS Number:
92693-02-2
Molecular Weight:
322.48
Molecular Formula:
C20H34O3
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
15(S)-HETrE is the hydroxy-trienoic acid resulting from 15-lipoxygenation of DGLA. It is an inhibitor of 5-LO in human PMNL with an IC50 value of 4.6 μM. In RBL cells, 15(S)-HETrE inhibits 5-LO, but is about 1/20 as potent as 15(S)-HpETE (sc-200966).
15(S)-HETrE (CAS 92693-02-2) References
- Suppression of proto-oncogene (AP-1) in a model of skin epidermal hyperproliferation is reversed by topical application of 13-hydroxyoctadecadienoic acid and 15-hydroxyeicosatrienoic acid. | Xi, S., et al. 2000. Prostaglandins Leukot Essent Fatty Acids. 62: 13-9. PMID: 10765974
- Suggested mechanism for the formation of 15-hydroxyeicosatrienoic acid by rat epidermal microsomes. | Van Wauwe, J., et al. 1992. Eicosanoids. 5: 141-6. PMID: 1292524
- 15-lipoxygenase metabolites of gamma-linolenic acid/eicosapentaenoic acid suppress growth and arachidonic acid metabolism in human prostatic adenocarcinoma cells: possible implications of dietary fatty acids. | Vang, K. and Ziboh, VA. 2005. Prostaglandins Leukot Essent Fatty Acids. 72: 363-72. PMID: 15850718
- Soluble epoxide hydrolase in the generation and maintenance of high blood pressure in spontaneously hypertensive rats. | Koeners, MP., et al. 2011. Am J Physiol Endocrinol Metab. 300: E691-8. PMID: 21266668
- Evening Primrose (Oenothera biennis) Biological Activity Dependent on Chemical Composition. | Timoszuk, M., et al. 2018. Antioxidants (Basel). 7: PMID: 30110920
- Influence of Dietary Inulin on Fecal Microbiota, Cardiometabolic Risk Factors, Eicosanoids, and Oxidative Stress in Rats Fed a High-Fat Diet. | Miralles-Pérez, B., et al. 2022. Foods. 11: PMID: 36553814
- Structural requirements for the inhibition of 5-lipoxygenase by 15-hydroxyeicosa-5,8,11,13-tetraenoic acid analogues. | Haviv, F., et al. 1987. J Med Chem. 30: 254-63. PMID: 3806609
- The suppression of 5-lipoxygenation of arachidonic acid in human polymorphonuclear leucocytes by the 15-lipoxygenase product (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoic acid: structure-activity relationship and mechanism of action. | Petrich, K., et al. 1996. Biochem J. 314 (Pt 3): 911-6. PMID: 8615788
- gamma-Linolenic acid-containing diet attenuates bleomycin-induced lung fibrosis in hamsters. | Ziboh, VA., et al. 1997. Lipids. 32: 759-67. PMID: 9252965
Inhibitor of:
5-LO, and Enzyme.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
15(S)-HETrE, 25 µg | sc-205043 | 25 µg | $120.00 | |||
15(S)-HETrE, 50 µg | sc-205043A | 50 µg | $200.00 |