Molecular structure of 15(S)-Fluprostenol isopropyl ester, CAS Number: 157283-68-6
15(S)-Fluprostenol isopropyl ester (CAS 157283-68-6)
Application:
15(S)-Fluprostenol isopropyl ester is an unnatural C-15 epimer of Travoprost
CAS Number:
157283-68-6
Molecular Weight:
500.6
Molecular Formula:
C26H35F3O6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
The unnatural C-15 epimer of Travoprost. Travoprost is the Alcon trade name for fluprostenol isopropyl ester, (Flu-Ipr) an F-series prostaglandin analog that has been approved for use as an ocular hypotensive drug.1,2 Flu-Ipr is a prodrug which is converted by esterase enzymatic activity in the cornea to yield the corresponding free acid. The free acid, fluprostenol, is a potent FP receptor agonist.3 In human and animal models of glaucoma, FP receptor agonist activity corresponds very closely with intraocular hypotensive activity. Inversion of the stereochemistry at the 15 position of ocular hypotensive prostaglandins generally lowers the potency approximately 100 fold.4
15(S)-Fluprostenol isopropyl ester (CAS 157283-68-6) References
- The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. | Abramovitz, M., et al. 2000. Biochim Biophys Acta. 1483: 285-93. PMID: 10634944
- Preclinical efficacy of travoprost, a potent and selective FP prostaglandin receptor agonist. | Hellberg, MR., et al. 2001. J Ocul Pharmacol Ther. 17: 421-32. PMID: 11765147
- Preclinical pharmacology of latanoprost, a phenyl-substituted PGF2 alpha analogue. | Stjernschantz, J., et al. 1995. Adv Prostaglandin Thromboxane Leukot Res. 23: 513-8. PMID: 7732899
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FPR.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
15(S)-Fluprostenol isopropyl ester, 1 mg | sc-220634 | 1 mg | $136.00 | |||
15(S)-Fluprostenol isopropyl ester, 5 mg | sc-220634A | 5 mg | $615.00 |