Molecular structure of 15(S)-Fluprostenol, CAS Number: 54276-24-3
15(S)-Fluprostenol (CAS 54276-24-3)
Alternate Names:
9α, 11α, 15S- trihydroxy- 16- (3- (trifluoromethyl)phenoxy)- 17, 18, 19, 20- tetranor- prosta- 5Z, 13E- dien- 1- oic acid
Application:
15(S)-Fluprostenol is a potent FP receptor agonist
CAS Number:
54276-24-3
Molecular Weight:
458.5
Molecular Formula:
C23H29F3O6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
A prodrug (Travoprost) which is converted by esterase enzymatic activity in the cornea to yield the corresponding free acid.1 The free acid, (+)-15(R)-fluprostenol, is a potent FP receptor agonist.2 The 15(R)-epimers of most prostaglandins are about 100 times less potent than the natural, 15(S)-isomers. However, the neighboring phenoxy group at C-16 reverses the absolute configuration at C-15 in the fluprostenol series. Therefore, 15(S)-fluprostenol is less active as an FP agonist than 15(R)-fluprostenol.
15(S)-Fluprostenol (CAS 54276-24-3) References
1 Stjernschantz, J., Resul, B. Phenyl substituted prostaglandin analogs for glaucoma treatment. Drugs of the Future 17 691-704 (1992). 2 Abramovitz, M., Adam, M., Boie, Y., et al. The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. Biochim Biophys Acta 1483 285-293 (2000).Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
15(S)-Fluprostenol, 1 mg | sc-220633 | 1 mg | $65.00 | |||
15(S)-Fluprostenol, 5 mg | sc-220633A | 5 mg | $295.00 |