Molecular structure of 15(S)-15-methyl Prostaglandin E2, CAS Number: 35700-27-7
15(S)-15-methyl Prostaglandin E2 (CAS 35700-27-7)
Application:
15(S)-15-methyl Prostaglandin E2 is a potent analog of PGE2 demonstrating potent gastric antisecretory activities
CAS Number:
35700-27-7
Purity:
≥98%
Molecular Weight:
366.5
Molecular Formula:
C21H34O5
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
15(S)-15-methyl PGE2 is a metabolically stable, potent analog of PGE2 (sc-210225), that has demonstrated potent gastric anti-secretory activities. This compound has been shown to bind to human myometrium with twice the affinity of PGE2 and is ten times more potent than PGE1(sc-201223) in contracting uterine smooth muscle. Also shown to dose-dependently inhibit gastric acid secretion and increase the total output, and rate of output of duodenal bicarbonate secretion.
15(S)-15-methyl Prostaglandin E2 (CAS 35700-27-7) References
- Midtrimester abortion induced by serial intramuscular injections of 15(S)-15-methyl-prostaglandin E2 methyl ester. | Lauersen, NH., et al. 1975. Am J Obstet Gynecol. 123: 665-70. PMID: 1200057
- The effects of nocloprost, nileprost, iloprost and (15 S)-15-methyl-PGE2 on gastric mucosal damage induced by stress, indomethacin and ethanol. | Zengil, H., et al. 1990. Prostaglandins Leukot Essent Fatty Acids. 40: 13-6. PMID: 1697972
- Gastric antisecretory and antiulcer properties of PGE2, 15-methyl PGE2, and 16, 16-dimethyl PGE2. Intravenous, oral and intrajejunal administration. | Robert, A., et al. 1976. Gastroenterology. 70: 359-70. PMID: 174967
- Acid-promoted epimerization of arbaprostil, 15(R)-15-methylprostaglandin E2, elicits gastric antisecretory activities in rats. | Takanashi, H., et al. 1991. Jpn J Pharmacol. 57: 559-64. PMID: 1803067
- Effects of 15(S)-15-methyl prostaglandin E2 methyl ester on phospholipid metabolism in rat gastric mucosa. | Nishizawa, Y. and Moriga, M. 1989. Biochem Pharmacol. 38: 955-60. PMID: 2930596
- Permeability effects of the E2 prostaglandins on canine gastric mucosa. | Bolton, JP. and Cohen, MM. 1979. Can J Physiol Pharmacol. 57: 1082-7. PMID: 509363
- The effect of cimetidine and 15(S) 15-methyl prostaglandin E2 on the healing of laser-induced gastric mucosal damage. | MacLeod, IA., et al. 1982. Gastrointest Endosc. 28: 166-8. PMID: 6890004
- The effect of orally administered prostaglandins on gastric mucus secretion in the rat. | Mahoney, JM. and Waterbury, LD. 1981. Prostaglandins Med. 7: 101-7. PMID: 7280123
- Prostaglandin E1 specific binding in human myometrium. | Kimball, FA., et al. 1975. Biol Reprod. 13: 479-89. PMID: 816397
- Abortifacient effects of prostaglandin E2 in the pigtailed macaque (Macaca nemestrina). | Lewis, JK. and Luthy, DA. 1975. J Med Primatol. 7: 319-23. PMID: 830037
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
15(S)-15-methyl Prostaglandin E2, 500 µg | sc-223170 | 500 µg | $92.00 | |||
15(S)-15-methyl Prostaglandin E2, 1 mg | sc-223170A | 1 mg | $174.00 |