Molecular structure of 15(R)-Iloprost, CAS Number: 85026-51-3
15(R)-Iloprost (CAS 85026-51-3)
Application:
15(R)-Iloprost is a second generation structural analog of prostacyclin
CAS Number:
85026-51-3
Purity:
>97%
Molecular Weight:
360.5
Molecular Formula:
C22H32O4
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
A second generation structural analog of prostacyclin (PGI2) that has roughly a ten-fold greater potency than the first generation stable analogs, typified by carbaprostacyclin.1 Iloprost binds with equal affinity to the recombinant human IP and EP receptors with a Ki of 11 nM.2 15(R)-Iloprost is the "unnatural" or inverted C-15 epimer of iloprost. This transformation frequently attenuates the biological agonist activity of prostaglandin analogs by several orders of magnitude. Currently, there are no literature reports on the biological activity of 15(R)-iloprost.
15(R)-Iloprost (CAS 85026-51-3) References
1 Schrör, K., Darius, H., Matzky, R., et al. The antiplatelet and cardiovascular actions of a new carbacyclin derivative (ZK36374) - equipotent to PGI2 in vitro. Naunyn-Schmiedeberg's Arch Pharmacol 316 252-255 (1981). 2 Abramovitz, M., Adam, M., Boie, Y., et al. The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. Biochim Biophys Acta 1483 285-293 (2000).Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
15(R)-Iloprost, 500 µg | sc-205033 | 500 µg | $176.00 | |||
15(R)-Iloprost, 1 mg | sc-205033A | 1 mg | $334.00 |