Molecular structure of 15-Lipoxygenase Inhibitor I, CAS Number: 928853-86-5
15-Lipoxygenase Inhibitor I (CAS 928853-86-5)
Alternate Names:
4-methyl-2-(4-methylpiperazinyl)pyrimido[4,5-b]benzothiazine
Application:
15-Lipoxygenase Inhibitor I is an inhibitor of 15-LO (15-lipoxygenase)
CAS Number:
928853-86-5
Purity:
≥98%
Molecular Weight:
313.4
Molecular Formula:
C16H19N5S
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
15-Lipoxygenase (15-LO) Inhibitor I is a heterocyclic pyrimidobenzothiazine compound which inhibits 15-LO with an IC50 value of 18 μM. Studies indicate that 15-Lipoxygenase has biological significance as a mediator of inflammation, thrombosis, and cancer via the oxidation products of the enzyme. It is believed that 15-Lipoxygenase Inhibitor I functions as an inhibitor by interfering with the redox cycle of 15-Lipoxygenase. Furthermore, 15-Lipoxygenase Inhibitor I acts as a catalyzing agent in the oxidation of polyunsaturated fatty acids.
15-Lipoxygenase Inhibitor I (CAS 928853-86-5) References
- 15-lipoxygenase: a Janus enzyme? | Chanez, P., et al. 2002. Am J Respir Cell Mol Biol. 27: 655-8. PMID: 12444024
- Design and synthesis of pyrimido[4,5-b][1,4]benzothiazine derivatives, as potent 15-lipoxygenase inhibitors. | Bakavoli, M., et al. 2007. Bioorg Med Chem. 15: 2120-6. PMID: 17210254
- Synthesis and SAR studies of mono O-prenylated coumarins as potent 15-lipoxygenase inhibitors. | Iranshahi, M., et al. 2012. Eur J Med Chem. 57: 134-42. PMID: 23047230
- 2-Prenylated m-dimethoxybenzenes as potent inhibitors of 15-lipo-oxygenase: inhibitory mechanism and SAR studies. | Jabbari, A., et al. 2016. Chem Biol Drug Des. 88: 460-9. PMID: 27113261
- The importance of 15-lipoxygenase inhibitors in cancer treatment. | Orafaie, A., et al. 2018. Cancer Metastasis Rev. 37: 397-408. PMID: 29882120
- Design and synthesis of new esters of terpenoid alcohols as 15-lipoxygenase inhibitors. | Sadeghian, H., et al. 2018. Iran J Basic Med Sci. 21: 738-744. PMID: 30140414
- Design, synthesis, and structure-activity relationship study of O-prenylated 3-acetylcoumarins as potent inhibitors of soybean 15-lipoxygenase. | Zerangnasrabad, S., et al. 2021. Drug Dev Res. 82: 826-834. PMID: 33416204
- Investigating the effects of two novel 4-MMPB analogs as potent lipoxygenase inhibitors for prostate cancer treatment. | Iranpour, S., et al. 2021. J Biol Res (Thessalon). 28: 10. PMID: 33947474
- Synthesis of new series of pyrimido [4, 5-b][1, 4] benzothiazines as 15-lipoxygenase inhibitors and study of their inhibitory mechanism | Nikpour, M., Mousavian, M., Davoodnejad, M., Alimardani, M., & Sadeghian, H. 2013. Medicinal Chemistry Research. 22: 5036-5043.
- Synthesis of new derivatives of 10 H-benzo [b] pyridazino [3, 4-e][1, 4] thiazines | Arghiani, Z., Seyedi, S. M., Bakavoli, M., & Nikpour, M. 2015. Heterocyclic Communications. 21(4): 215-218.
Inhibitor of:
15-LO.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
15-Lipoxygenase Inhibitor I, 500 µg | sc-220625 | 500 µg | $34.00 | |||
15-Lipoxygenase Inhibitor I, 1 mg | sc-220625A | 1 mg | $64.00 |