Molecular structure of 15-Keto-prostaglandin E2, CAS Number: 26441-05-4
15-Keto-prostaglandin E2 (CAS 26441-05-4)
Alternate Names:
9,15-dioxo-11α-hydroxy-prosta-5Z,13E-dien-1-oic acid
Application:
15-Keto-prostaglandin E2 is a metabolite of PGE2 shown to be 1.3 fold more potent in relaxing guinea pig trachea than PGE2
CAS Number:
26441-05-4
Molecular Weight:
350.45
Molecular Formula:
C20H30O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
15-Keto-prostaglandin E2 is biosynthesized via 15-hydroxyprostaglandin dehydrogenase, and has been shown to be 1.3 times more potent than Prostaglandin E2 (PGE2; sc-201225) in relaxing guinea pig trachea. This metabolite of PGE2 did not show any significant activity in other systems used to gauge PGE2 activity; however, it is difficult to distinguish in vivo the proportions of PGE2 and its metabolites that are performing biological function throughout the organism - these metabolites might play important roles in some biochemical pathways, and are therefore of interest to researchers.
15-Keto-prostaglandin E2 (CAS 26441-05-4) References
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- 15-Hydroxyprostaglandin dehydrogenase-derived 15-keto-prostaglandin E2 inhibits cholangiocarcinoma cell growth through interaction with peroxisome proliferator-activated receptor-γ, SMAD2/3, and TAP63 proteins. | Lu, D., et al. 2015. J Biol Chem. 290: 28353. PMID: 26590294
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- Correction: 15-keto-prostaglandin E2 activates host peroxisome proliferator-activated receptor gamma (PPAR-γ) to promote Cryptococcus neoformans growth during infection. | Evans, RJ., et al. 2020. PLoS Pathog. 16: e1009058. PMID: 33147298
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Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
15-Keto-prostaglandin E2, 500 µg | sc-201233A | 500 µg | $78.00 | |||
15-Keto-prostaglandin E2, 1 mg | sc-201233 | 1 mg | $150.00 | |||
15-Keto-prostaglandin E2, 5 mg | sc-201233B | 5 mg | $625.00 | |||
15-Keto-prostaglandin E2, 10 mg | sc-201233C | 10 mg | $1095.00 |