15-deoxy-Δ12,14-Prostaglandin J2 solution (CAS 87893-55-8)
QUICK LINKS
15-deoxy-Δ12,14-Prostaglandin J2 solution is a biologically active lipid mediator that acts as a potent anti-inflammatory agent. It functions by modulating the activity of various transcription factors and signaling pathways involved in the inflammatory response. It may inhibit the activation of NF-κB, a key regulator of pro-inflammatory gene expression, and to promote the expression of anti-inflammatory genes.15-deoxy-Δ12,14-Prostaglandin J2 solution exerts its anti-inflammatory effects by activating the peroxisome proliferator-activated receptor gamma (PPAR-γ). At the cellular level, 15-deoxy-Δ12,14-Prostaglandin J2 solution suppresses the production of pro-inflammatory cytokines and chemokines, thereby attenuating the inflammatory cascade. 15-deoxy-Δ12,14-Prostaglandin J2 solution functions as a modulator of inflammatory signaling pathways, exerting anti-inflammatory effects through the regulation of gene expression and immune responses.
15-deoxy-Δ12,14-Prostaglandin J2 solution (CAS 87893-55-8) References
- 15-deoxy-delta 12,14-prostaglandin J2 inhibits multiple steps in the NF-kappa B signaling pathway. | Straus, DS., et al. 2000. Proc Natl Acad Sci U S A. 97: 4844-9. PMID: 10781090
- 15-deoxy-delta 12,14-prostaglandin J2. A prostaglandin D2 metabolite generated during inflammatory processes. | Shibata, T., et al. 2002. J Biol Chem. 277: 10459-66. PMID: 11786541
- 15-Deoxy-Delta(12,14)-prostaglandin J2 inhibits the expression of proinflammatory genes in human blood monocytes via a PPAR-gamma-independent mechanism. | Hinz, B., et al. 2003. Biochem Biophys Res Commun. 302: 415-20. PMID: 12604364
- Biosynthesis of 15-deoxy-delta12,14-PGJ2 and the ligation of PPARgamma. | Bell-Parikh, LC., et al. 2003. J Clin Invest. 112: 945-55. PMID: 12975479
- Effect of rosiglitazone and 15-deoxy-Delta12,14-prostaglandin J2 on bleomycin-induced lung injury. | Genovese, T., et al. 2005. Eur Respir J. 25: 225-34. PMID: 15684285
- The anti-inflammatory effects of selenium are mediated through 15-deoxy-Delta12,14-prostaglandin J2 in macrophages. | Vunta, H., et al. 2007. J Biol Chem. 282: 17964-17973. PMID: 17439952
- 15-deoxy-Delta(12,14)-prostaglandin J2 induces vascular endothelial cell apoptosis through the sequential activation of MAPKS and p53. | Ho, TC., et al. 2008. J Biol Chem. 283: 30273-88. PMID: 18718914
- Regulation of Nrf2-dependent gene expression by 15-deoxy-Delta12,14-prostaglandin J2. | Kansanen, E., et al. 2009. Free Radic Biol Med. 47: 1310-7. PMID: 19573595
- M2 microglia promotes neurogenesis and oligodendrogenesis from neural stem/progenitor cells via the PPARγ signaling pathway. | Yuan, J., et al. 2017. Oncotarget. 8: 19855-19865. PMID: 28423639
- Albumin-catalyzed metabolism of prostaglandin D2. Identification of products formed in vitro. | Fitzpatrick, FA. and Wynalda, MA. 1983. J Biol Chem. 258: 11713-8. PMID: 6578214
- 9-Deoxy-delta 9, delta 12-13,14-dihydroprostaglandin D2, a metabolite of prostaglandin D2 formed in human plasma. | Kikawa, Y., et al. 1984. Proc Natl Acad Sci U S A. 81: 1317-21. PMID: 6584883
- 15-Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma. | Forman, BM., et al. 1995. Cell. 83: 803-12. PMID: 8521497
- A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor gamma and promotes adipocyte differentiation. | Kliewer, SA., et al. 1995. Cell. 83: 813-9. PMID: 8521498
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
15-deoxy-Δ12,14-Prostaglandin J2 solution, 1 mg | sc-205018 | 1 mg | $71.00 | |||
15-deoxy-Δ12,14-Prostaglandin J2 solution, 5 mg | sc-205018A | 5 mg | $431.00 |