Molecular structure of 15-deoxy-Δ12,14-Prostaglandin J2-d4, CAS Number: 1542166-82-4
15-deoxy-Δ12,14-Prostaglandin J2-d4 (CAS 1542166-82-4)
Alternate Names:
11-oxo-prosta-5Z,9,12E,14E-tetraen-1-oic-3,3,4,4-d4 acid, 15-deoxy-Δ12,14-PGJ2-d4, 15d-PGJ2-d4
CAS Number:
1542166-82-4
Molecular Weight:
320.5
Molecular Formula:
C20H24D4O3
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
15-deoxy-Δ12,14-Prostaglandin J2-d4 contains four deuterium atoms at the 3, 3′, 4, and 4′ positions. Intended for use as an internal standard for the quantification of 15-deoxy-Δ12,14-PGJ2 by GC- or LC-mass spectrometry. A metabolite of PGJ2 and formed from PGD2 the elimination of two molecules of water. It binds selectively to PPARγ with an EC50 of 2 µM in a murine chimera system.1,2 More potent than PGD2, Δ12-PGJ2, and PGJ2 in stimulating lipogenesis in C3H10T1/2 cells. The EC50 for induction of adipocyte differentiation in cultured fibroblasts is 7 µM.
15-deoxy-Δ12,14-Prostaglandin J2-d4 (CAS 1542166-82-4) References
- On the metabolism of prostaglandin E1 administered intravenously to human volunteers. | Peskar, BA., et al. 1991. J Physiol Pharmacol. 42: 327-31. PMID: 1793892
- On the metabolism of prostaglandins E 1 and E 2 in man. | Hamberg, M. and Samuelsson, B. 1971. J Biol Chem. 246: 6713-21. PMID: 5126221
- Comparison of the inhibitory effect of E-prostaglandins in human and rabbit platelet-rich plasma and washed platelets. | Kobzar, G., et al. 1993. Comp Biochem Physiol C Comp Pharmacol Toxicol. 106: 489-94. PMID: 7904921
- In vivo formation of prostaglandin E1 and prostaglandin E2 in atopic dermatitis. | Leonhardt, A., et al. 1997. Br J Dermatol. 136: 337-40. PMID: 9115911
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| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
15-deoxy-Δ12,14-Prostaglandin J2-d4, 25 µg | sc-220618 | 25 µg | $160.00 | |||
15-deoxy-Δ12,14-Prostaglandin J2-d4, 50 µg | sc-220618A | 50 µg | $305.00 |