15-deoxy-Δ12,14-Prostaglandin J2-biotinamide
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One of the cyclopentenone PGs, which have documented metabolic (peroxisome proliferator-activated receptor γ-activating), antimitotic, and antiproliferative effects.1,2,3 The activity of the compounds in this class, which includes PGs in both the A- and J-series, may result from changes in gene expression and the interaction with non-classical pathways. An affinity probe that allows 15-deoxy-Δ12,14-PGJ2 to be detected through an interaction with the biotin ligand. 15-deoxy-Δ12,14-PGJ2-biotinamide was designed to allow 15-deoxy-Δ12,14-PGJ2 to be detected in complexes with nuclear receptors and/or nucleic acid or protein binding partners. It is thus a tool to be used in the general elucidation of the mechanism of action of the cyclopentenone PGs.
15-deoxy-Δ12,14-Prostaglandin J2-biotinamide References
1 Krakoff, L.R., Vlachakis, N., Mendlowitz, M., et al. Differential effect of prostaglandin A1 in hypertensive patients with low, normal and high renin. Clin Sci Mol Med 48 311s-313s (1975). 2 Kikuchi, Y., Kita, T., Hirata, J., et al. Preclinical studies of antitumor prostaglandins by using human ovarian cancer cells. Cancer Metast Rev 13 309-315 (1994). 3 Mueller, E., Drori, S., Aiyer, A., et al. Genetic analysis of adipogenesis through peroxisome proliferator-activated receptor γ isoforms. J Biol Chem 277(44) 41925-41930 (2002).Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
15-deoxy-Δ12,14-Prostaglandin J2-biotinamide, 50 µg | sc-220617 | 50 µg | $192.00 | |||
15-deoxy-Δ12,14-Prostaglandin J2-biotinamide, 100 µg | sc-220617A | 100 µg | $364.00 |