15-deoxy-Δ12,14-Prostaglandin J2-2-glycerol ester
Alternate Names:
15-deoxy-Δ12,14-PGJ2-2-glycerol ester
Application:
15-deoxy-Δ12,14-Prostaglandin J2-2-glycerol ester is formed from PGD2 by the elimination of two molecules of water
Molecular Weight:
390.51
Molecular Formula:
C23H34O5
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Formed from PGD2 by the elimination of two molecules of water. Binds selectively to PPARγ with an EC50 value of 2 µM in a murine chimera system.1,2 More potent than PGD2, Δ12-PGJ2, and PGJ2 in stimulating lipogenesis in C3H10T1/2 cells. The EC50 value for induction of adipocyte differentiation in cultured fibroblasts is 7 µM.1 PG glycerol esters are generated by the action of cyclooxygenase-2 on the endocannabinoid 2-arachidonyl glycerol.3 The biosynthesis of PGH, PGD, PGE, PGF, and TXA-2-glyceryl ester compounds have all been documented and though the stability and metabolism of these PG products has been investigated,4 little is known about their intrinsic biological activity.
15-deoxy-Δ12,14-Prostaglandin J2-2-glycerol ester References
- Metabolism of prostaglandin glycerol esters and prostaglandin ethanolamides in vitro and in vivo. | Kozak, KR., et al. 2001. J Biol Chem. 276: 36993-8. PMID: 11447235
- Metabolism of the endocannabinoids, 2-arachidonylglycerol and anandamide, into prostaglandin, thromboxane, and prostacyclin glycerol esters and ethanolamides. | Kozak, KR., et al. 2002. J Biol Chem. 277: 44877-85. PMID: 12244105
- Sequence analysis and structure prediction of ABHD16A and the roles of the ABHD family members in human disease. | Xu, J., et al. 2018. Open Biol. 8: PMID: 29794032
- Decrease of the pro-inflammatory M1-like response by inhibition of dipeptidyl peptidases 8/9 in THP-1 macrophages - quantitative proteomics of the proteome and secretome. | Suski, M., et al. 2020. Mol Immunol. 127: 193-202. PMID: 32998073
- Mirtronic miR-4646-5p promotes gastric cancer metastasis by regulating ABHD16A and metabolite lysophosphatidylserines. | Yang, L., et al. 2021. Cell Death Differ. 28: 2708-2727. PMID: 33875796
- Auricularia polytricha ethanol crude extract from sequential maceration induces lipid accumulation and inflammatory suppression in RAW264.7 macrophages. | Sangphech, N., et al. 2021. Food Funct. 12: 10563-10570. PMID: 34571527
- Ergosterol isolated from cloud ear mushroom (Auricularia polytricha) attenuates bisphenol A-induced BV2 microglial cell inflammation. | Sillapachaiyaporn, C., et al. 2022. Food Res Int. 157: 111433. PMID: 35761673
- Gut-Brain Axis: Insights from Hippocampal Neurogenesis and Brain Tumor Development in a Mouse Model of Experimental Colitis Induced by Dextran Sodium Sulfate. | Vitali, R., et al. 2022. Int J Mol Sci. 23: PMID: 36232813
- 15-Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma. | Forman, BM., et al. 1995. Cell. 83: 803-12. PMID: 8521497
- A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor gamma and promotes adipocyte differentiation. | Kliewer, SA., et al. 1995. Cell. 83: 813-9. PMID: 8521498
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
15-deoxy-Δ12,14-Prostaglandin J2-2-glycerol ester, 100 µg | sc-220616 | 100 µg | $78.00 | |||
15-deoxy-Δ12,14-Prostaglandin J2-2-glycerol ester, 500 µg | sc-220616A | 500 µg | $352.00 |