1400 W (CAS 214358-33-5)
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1400 W is a highly potent and selective inhibitor of inducible NOS2 (iNOS). Studies show that in the presence of 1400 W there is reduced tumor growth in EMT6 murine mammary adenocarcinoma. 1400W is a weak inhibitor of NOS3 (eNOS) and NOS1 (nNOS). It has been observed that 1400 W suppressed the ulcerogenic response and reduced oxidative pentose phosphate cycle (OPPC) in RAW 264.7 cells. In both in vivo (within living organisms) and in vitro (lab-based) studies, 1400W- is employed to shed light on its mechanism of action, biological activity, and biochemical and physiological effects. As an agonist of the μ-opioid receptor, which is a G-protein coupled receptor activated by endogenous opioid peptides, like endorphins and enkephalins, 1400W binds to this receptor and triggers a signaling cascade, leading to the release of neurotransmitters such as serotonin, dopamine, and norepinephrine. These interactions contribute to the analgesic, sedative, anxiolytic, and antinociceptive effects exhibited by 1400W.
1400 W (CAS 214358-33-5) References
- Apocynin and 1400 W prevents airway hyperresponsiveness during allergic reactions in mice. | Muijsers, RB., et al. 2001. Br J Pharmacol. 134: 434-40. PMID: 11564663
- Efficacy of 1400 W, a novel inhibitor of inducible nitric oxide synthase, in preventing interleukin-1beta-induced suppression of pancreatic islet function in vitro and multiple low-dose streptozotocin-induced diabetes in vivo. | Rydgren, T. and Sandler, S. 2002. Eur J Endocrinol. 147: 543-51. PMID: 12370118
- Relationship between iNOS expression and aortic cell proliferation and apoptosis in an elastase-induced model of aorta aneurysm and the effect of 1400 W administration. | Sigala, F., et al. 2005. Surgery. 137: 447-56. PMID: 15800493
- pO(2)-dependent NO production determines OPPC activity in macrophages. | Robinson, MA., et al. 2010. Free Radic Biol Med. 48: 189-95. PMID: 19822207
- Role of endothelial nitric oxide synthase in aggravation of indomethacin-induced gastric damage in adjuvant arthritic rats. | Kato, S., et al. 2009. J Physiol Pharmacol. 60: 147-55. PMID: 20065509
- Antihypertensive effects of inducible nitric oxide synthase inhibition in experimental pre-eclampsia. | Amaral, LM., et al. 2013. J Cell Mol Med. 17: 1300-7. PMID: 23890248
- N-[3-(aminomethyl)benzyl]acetamidine (1400 W) as a potential immunomodulatory agent. | Mertas, A., et al. 2014. Oxid Med Cell Longev. 2014: 491214. PMID: 24995119
- NOS-2 Inhibition in Phosgene-Induced Acute Lung Injury. | Filipczak, PT., et al. 2015. Toxicol Sci. 146: 89-100. PMID: 25870319
- Antinociceptive effect of 1400 W, an inhibitor of inducible nitric oxide synthase, following hind paw incision in rats. | Gautam, M., et al. 2015. Nitric Oxide. 50: 98-104. PMID: 26362773
- Sepsis downregulates aortic Notch signaling to produce vascular hyporeactivity in mice. | Singh, V., et al. 2022. Sci Rep. 12: 2941. PMID: 35190630
- A Nurr1 ligand C-DIM12 attenuates brain inflammation and improves functional recovery after intracerebral hemorrhage in mice. | Kinoshita, K., et al. 2022. Sci Rep. 12: 11009. PMID: 35773404
- Simvastatin protects against intestinal ischemia/reperfusion-induced pulmonary artery dysfunction. | Peres, EC., et al. 2022. Life Sci. 306: 120851. PMID: 35926590
- 1400 W, a selective inducible nitric oxide synthase inhibitor, mitigates early neuroinflammation and nitrooxidative stress in diisopropylfluorophosphate-induced short-term neurotoxicity rat model. | Massey, N., et al. 2023. Front Mol Neurosci. 16: 1125934. PMID: 37008784
- 1400W is a slow, tight binding, and highly selective inhibitor of inducible nitric-oxide synthase in vitro and in vivo. | Garvey, EP., et al. 1997. J Biol Chem. 272: 4959-63. PMID: 9030556
- Selective inhibition of inducible nitric oxide synthase inhibits tumor growth in vivo: studies with 1400W, a novel inhibitor. | Thomsen, LL., et al. 1997. Cancer Res. 57: 3300-4. PMID: 9242464
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
1400 W, 5 mg | sc-3564 | 5 mg | $56.00 | |||
1400 W, 25 mg | sc-3564A | 25 mg | $160.00 |