Molecular structure of 14,15-dehydro Leukotriene B4, CAS Number: 114616-11-4
14,15-dehydro Leukotriene B4 (CAS 114616-11-4)
Alternate Names:
14,15-Dehydro-LTB4
Application:
14,15-dehydro Leukotriene B4 is an LTB4 receptor antagonist
CAS Number:
114616-11-4
Molecular Weight:
334.5
Molecular Formula:
C20H30O4
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
14,15-dehydro LTB4 has been shown to be an LTB4 receptor antagonist that has a much stronger binding affinity for BLT1 than BLT2. It has also been observed to inhibit LTB4-induced release of lysozymes from rat polymorphonuclear leukoctyes.
14,15-dehydro Leukotriene B4 (CAS 114616-11-4) References
- A novel hepatointestinal leukotriene B4 receptor. Cloning and functional characterization. | Wang, S., et al. 2000. J Biol Chem. 275: 40686-94. PMID: 11006272
- Prostaglandins and leukotrienes: advances in eicosanoid biology. | Funk, CD. 2001. Science. 294: 1871-5. PMID: 11729303
- Sphingosine 1-phosphate and dioleoylphosphatidic acid are low affinity agonists for the orphan receptor GPR63. | Niedernberg, A., et al. 2003. Cell Signal. 15: 435-46. PMID: 12618218
- Leukotriene B4 in inflammation. | Ford-Hutchinson, AW. 1990. Crit Rev Immunol. 10: 1-12. PMID: 2155000
- Some newly synthesized leukotriene B4 analogs inhibit LTB4-induced lysozyme release from rat polymorphonuclear leukocytes. | Shimazaki, T., et al. 1990. Prostaglandins. 39: 459-67. PMID: 2160678
- Leukotriene B4 and inflammatory disease. | McMillan, RM. and Foster, SJ. 1988. Agents Actions. 24: 114-9. PMID: 2841828
- Enzymatic hydration of leukotriene A4. Purification and characterization of a novel epoxide hydrolase from human erythrocytes. | McGee, J. and Fitzpatrick, F. 1985. J Biol Chem. 260: 12832-7. PMID: 2995393
- Leukotriene A: stereochemistry and enzymatic conversion to leukotriene B. | Rådmark, O., et al. 1980. Biochem Biophys Res Commun. 92: 954-61. PMID: 6244821
- 14,15-Dehydroleukotriene A4: a specific substrate for leukotriene C4 synthase. | Sala, A., et al. 1997. Biochem J. 328 (Pt 1): 225-9. PMID: 9359857
Inhibitor of:
LTB4R2, and P2Y7.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
14,15-dehydro Leukotriene B4, 25 µg | sc-205010 | 25 µg | $132.00 | |||
14,15-dehydro Leukotriene B4, 50 µg | sc-205010A | 50 µg | $232.00 |