13(S)-HODE (CAS 29623-28-7)

13(S)-HODE, cataloged under CAS number 29623-28-7, is the S-enantiomer of 13-hydroxyoctadecadienoic acid, a metabolite primarily formed through the enzymatic oxidation of linoleic acid by 15-lipoxygenases. This particular enantiomer is of significant interest in research due to its involvement in cellular signaling mechanisms. 13(S)-HODE plays a crucial role in modulating lipid signaling pathways that influence various cellular processes such as apoptosis, proliferation, and inflammation. As a signaling lipid, it is particularly noted for its ability to interact with specific receptors, including peroxisome proliferator-activated receptors (PPARs), which are integral to the regulation of lipid metabolism and immune responses. In research settings, 13(S)-HODE is often utilized to study its effects on endothelial cells, exploring how it influences vascular integrity and function. This compound is also used in studies examining the mechanisms behind oxidative stress and the cellular response to such stress, providing insights into how cells adapt to changes in their environment through lipid-derived mediators. The research involving 13(S)-HODE helps to uncover the complex dynamics of lipid signaling in cellular health and stress responses, offering a deeper understanding of the biochemical pathways that are essential for maintaining cellular homeostasis and responding to physiological challenges.