13(R)-HODE cholesteryl ester (CAS 330800-94-7)

13(R)-HODE cholesteryl ester, assigned CAS number 330800-94-7, is a lipid molecule formed by the esterification of 13(R)-hydroxyoctadecadienoic acid (13(R)-HODE) with cholesterol. The parent molecule, 13(R)-HODE, is an oxidized form of linoleic acid, produced through the enzymatic action of lipoxygenases, which specifically generate the R-stereoisomer. The formation of this cholesteryl ester significantly enhances the hydrophobic nature of 13(R)-HODE, facilitating its integration into lipid membranes, which is of substantial interest in biochemical research. Within the lipid bilayer of cells, 13(R)-HODE cholesteryl ester can influence membrane properties such as fluidity, permeability, and the function of embedded proteins, including receptors and enzymes. This interaction with cell membranes is crucial for understanding the modulation of cellular signals and the impact on various cellular processes. Researchers utilize this compound to explore the role of oxidized lipids in cellular signaling pathways and their potential to alter physiological responses under conditions of oxidative stress. By studying such mechanisms, the compound aids in elucidating the broader impacts of lipid peroxidation on cellular health and adaptability, providing insights into the complex dynamics of cellular lipidomics and their role in maintaining cellular homeostasis under stress conditions.