Molecular structure of 13,14-dihydro-16,16-difluoro Prostaglandin J2
13,14-dihydro-16,16-difluoro Prostaglandin J2
Molecular Weight:
372.5
Molecular Formula:
C20H30F2O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Prostaglandin J2 (PGJ2) is an analog of PGD2 that can inhibit both platelet aggregation and cell growth. However, it is not clear whether these effects are initiated by PGJ2 or a derivative. 13,14-dihydro-16,16-difluoro PGJ2 is an analog of PGJ2. While its biological activities have not been evaluated, it should be noted that the addition of two electron-withdrawing fluorine atoms has been used to stabilize prostanoids and significantly delay degradation in vivo. Importantly, 13,14-dihydro PGE1 has activity that is comparable to that of PGE1, suggesting that this analog of PGJ2 could be biologically active.
13,14-dihydro-16,16-difluoro Prostaglandin J2 References
- Prostaglandin J2--anti-tumour and anti-viral activities and the mechanisms involved. | Fukushima, M. 1990. Eicosanoids. 3: 189-99. PMID: 2073399
- On the metabolism of prostaglandins E 1 and E 2 in man. | Hamberg, M. and Samuelsson, B. 1971. J Biol Chem. 246: 6713-21. PMID: 5126221
- The biological activities of three metabolites of prostaglandin E 1. | Anggård, E. 1966. Acta Physiol Scand. 66: 509-10. PMID: 5951401
- On the identification and biological properties of prostaglandin J2. | Mahmud, I., et al. 1984. Prostaglandins Leukot Med. 16: 131-46. PMID: 6597446
- Synthesis and platelet aggregation inhibiting activity of prostaglandin D analogues. | Bundy, GL., et al. 1983. J Med Chem. 26: 790-9. PMID: 6854581
- Vascular relaxing activity and stability studies of 10,10-difluoro-13,14-dehydroprostacyclin. | Hatano, Y., et al. 1980. Proc Natl Acad Sci U S A. 77: 6846-50. PMID: 7005902
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
13,14-dihydro-16,16-difluoro Prostaglandin J2, 100 µg | sc-287302 | 100 µg | $37.00 | |||
13,14-dihydro-16,16-difluoro Prostaglandin J2, 500 µg | sc-287302A | 500 µg | $168.00 |