Molecular structure of 13,14-dihydro-16,16-difluoro Prostaglandin D2
13,14-dihydro-16,16-difluoro Prostaglandin D2
Alternate Names:
9a,15S-dihydroxy-11-oxo-16,16-difluoro-prosta-5Z-en-1-oic acid; 13,14-dihydro-16,16-difluoro PGD2
Application:
13,14-dihydro-16,16-difluoro Prostaglandin D2 is an analog of PGD2
Molecular Weight:
390.46
Molecular Formula:
C20H32F2O5
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Prostaglandin D2 (PGD2) plays important roles in vascular smooth muscle relaxation, the inhibition of platelet aggregation, and anaphylaxis. 13,14-dihydro-16,16-difluoro PGD2 is an analog of PGD2. While its biological activities have not been evaluated, it should be noted that the addition of two electron-withdrawing fluorine atoms has been used to stabilize prostanoids and significantly delay degradation in vivo. Importantly, 13,14-dihydro PGE1 has activity that is comparable to that of PGE1, suggesting that this analog of PGD2 could be biologically active.
13,14-dihydro-16,16-difluoro Prostaglandin D2 References
- On the metabolism of prostaglandins E 1 and E 2 in man. | Hamberg, M. and Samuelsson, B. 1971. J Biol Chem. 246: 6713-21. PMID: 5126221
- The biological activities of three metabolites of prostaglandin E 1. | Anggård, E. 1966. Acta Physiol Scand. 66: 509-10. PMID: 5951401
- Vascular relaxing activity and stability studies of 10,10-difluoro-13,14-dehydroprostacyclin. | Hatano, Y., et al. 1980. Proc Natl Acad Sci U S A. 77: 6846-50. PMID: 7005902
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
13,14-dihydro-16,16-difluoro Prostaglandin D2, 100 µg | sc-287300 | 100 µg | $32.00 | |||
13,14-dihydro-16,16-difluoro Prostaglandin D2, 500 µg | sc-287300A | 500 µg | $187.00 |