Molecular structure of 13,14-dihydro-15-keto Prostaglandin E2, CAS Number: 363-23-5
13,14-dihydro-15-keto Prostaglandin E2 (CAS 363-23-5)
Alternate Names:
13,14-dihydro-15-keto PGE2
Application:
13,14-dihydro-15-keto Prostaglandin E2 is a metabolite of PGE2 that is more stable than the parent compound
CAS Number:
363-23-5
Molecular Weight:
352.50
Molecular Formula:
C20H32O5
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
13,14-dihydro-15-keto Prostaglandin E2 (13,14-dihydro-15-keto PGE2) is a metabolite of PGE2 (sc-201225) biosynthesized by the enzymes 15-hydroxy PGDH and 15-oxo-PG delta13-reductase. This compound accumulates to detectable levels, and then undergoes further metabolism and chemical decomposition, giving it a relatively short half-life (~ 9 minutes), but that is longer than PGE2 (~ 2 minutes), allowing this compound to build up to appreciable levels during PGE2 expression. Receptor binding studies indicate that although metabolites of prostaglandins typically bind to EP receptors with lower affinity, they might still play an important role in these biochemical pathways.
13,14-dihydro-15-keto Prostaglandin E2 (CAS 363-23-5) References
- The measurement of the main PGE metabolite, 13,14-dihydro-15-keto prostaglandin E by radioimmunoassay using methyl oxime stabilization. | Kelly, RW., et al. 1992. Prostaglandins Leukot Essent Fatty Acids. 45: 185-9. PMID: 1589444
- Plasma, follicular, and uterine levels of prostaglandins in chickens laying soft-shelled and shell-less eggs. | Hester, PY., et al. 1991. Poult Sci. 70: 1585-93. PMID: 1886870
- Effects of sucralfate on gastroduodenal bicarbonate secretion and prostaglandin E2 metabolism. | Crampton, JR., et al. 1987. Am J Med. 83: 14-8. PMID: 3499075
- The radioimmunological estimation of 13, 14-dihydro-15-ketoprostaglandin E2 in plasma and cervical mucus. | Schlegel, W., et al. 1985. Horm Metab Res. 17: 685-8. PMID: 3936765
- On the metabolism of prostaglandins E 1 and E 2 in man. | Hamberg, M. and Samuelsson, B. 1971. J Biol Chem. 246: 6713-21. PMID: 5126221
- Acute phase reactants ceruloplasmin and haptoglobin and their relationship to plasma prostaglandins in rabbits bearing the VS2 carcinoma. | Voelkel, EF., et al. 1978. J Exp Med. 147: 1078-88. PMID: 650152
- A radioimmunoassay for the unstable pulmonary metabolites of prostaglandin E1 and E2: an indirect index of their in vivo disposition and pharmacokinetics. | Bothwell, W., et al. 1982. J Pharmacol Exp Ther. 220: 229-35. PMID: 6948952
- Prostaglandins release plasma 'reciprocal coupling factor' in anaesthetized rats. | Hoult, JR. and Moore, PK. 1981. Br J Pharmacol. 74: 485-7. PMID: 7032632
- The stability of 13,14-dihydro-15 keto-PGE2. | Fitzpatrick, FA., et al. 1980. Prostaglandins. 19: 917-31. PMID: 7384560
- Radioimmunoassay for 13,14-dihydro,15-keto-prostaglandin E2 in human plasma: applications and artifacts. | Metz, SA., et al. 1980. Adv Prostaglandin Thromboxane Res. 6: 183-5. PMID: 7386256
- Effects of hydrocortisone on the hypercalcemia and plasma levels of 13,14-dihydro-15-keto-prostaglandin E2 in mice bearing the HSDM1 fibrosarcoma. | Tashjian, AH., et al. 1977. Biochem Biophys Res Commun. 74: 199-207. PMID: 836278
- Two Gs-coupled prostaglandin E receptor subtypes, EP2 and EP4, differ in desensitization and sensitivity to the metabolic inactivation of the agonist. | Nishigaki, N., et al. 1996. Mol Pharmacol. 50: 1031-7. PMID: 8863851
- Plasma concentrations of 13,14-dihydro-15-keto-prostaglandin E2 in rabbits bearing the VX2 carcinoma: effects of hydrocortisone and indomethacin. | Tashjian, AH., et al. 1977. Prostaglandins. 14: 309-17. PMID: 897222
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
13,14-dihydro-15-keto Prostaglandin E2, 1 mg | sc-205000 | 1 mg | $74.00 | |||
13,14-dihydro-15-keto Prostaglandin E2, 5 mg | sc-205000A | 5 mg | $333.00 |