Molecular structure of 13,14-dihydro-15-keto Prostaglandin E1, CAS Number: 5094-14-4
13,14-dihydro-15-keto Prostaglandin E1 (CAS 5094-14-4)
See product citations (1)
Alternate Names:
13,14-dihydro-15-keto PGE1; 9,15-dioxo-11α-hydroxy-prostan-1-oic acid
Application:
13,14-dihydro-15-keto Prostaglandin E1 is a metabolite of PGE1 with much reduced biological activity
CAS Number:
5094-14-4
Molecular Weight:
354.5
Molecular Formula:
C20H34O5
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Product Citations
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
13,14-dihydro-15-keto Prostaglandin E1 is a metabolite of PGE1 with much reduced biological activity. This compound is a weak inhibitor of ADP-induced platelet aggregation in human PRP and washed platelets (IC50 = 54 and 200 muM, respectively). 13,14-dihydro-15-keto Prostaglandin E1 is a naturally existing prostaglandin distributed widely across various tissues in the body. It plays a vital role in numerous physiological processes, notably in the regulation of inflammation and the modulation of smooth muscle contraction.
13,14-dihydro-15-keto Prostaglandin E1 (CAS 5094-14-4) References
- On the metabolism of prostaglandin E1 administered intravenously to human volunteers. | Peskar, BA., et al. 1991. J Physiol Pharmacol. 42: 327-31. PMID: 1793892
- The role of the blood in metabolism of prostaglandin E1 in the cat lung. | Cozzini, BO. and Dawson, CA. 1977. Prostaglandins. 13: 587-97. PMID: 193152
- PLA2G2E-mediated lipid metabolism triggers brain-autonomous neural repair after ischemic stroke. | Nakamura, A., et al. 2023. Neuron. 111: 2995-3010.e9. PMID: 37490917
- On the metabolism of prostaglandins E 1 and E 2 in man. | Hamberg, M. and Samuelsson, B. 1971. J Biol Chem. 246: 6713-21. PMID: 5126221
- In vivo disposition of prostaglandin E1 via pharmacokinetic characterization of its pulmonary metabolite. | Verburg, M., et al. 1982. J Cardiovasc Pharmacol. 4: 980-5. PMID: 6185792
- Comparison of the inhibitory effect of E-prostaglandins in human and rabbit platelet-rich plasma and washed platelets. | Kobzar, G., et al. 1993. Comp Biochem Physiol C Comp Pharmacol Toxicol. 106: 489-94. PMID: 7904921
- FTIR spectral study of intramolecular hydrogen bonding in E-type of 15-keto-prostaglandins in dilute CCl4 solution: structure-activity relationships. | Takasuka, M. and Yamakawa, M. 1995. Bioorg Med Chem. 3: 459-69. PMID: 8581429
- Further identification of PGE1 metabolites formed in the cat lung. | Cozzini, BO. and Dawson, CA. 1977. Can J Physiol Pharmacol. 55: 311-3. PMID: 871963
- In vivo formation of prostaglandin E1 and prostaglandin E2 in atopic dermatitis. | Leonhardt, A., et al. 1997. Br J Dermatol. 136: 337-40. PMID: 9115911
- Interindividual variation in the enzymatic 15-keto-reduction of 13,14-dihydro-15-keto-prostaglandin E1 in human liver and in human erythrocytes. | Rady-Pentek, P., et al. 1997. Eur J Clin Pharmacol. 52: 147-53. PMID: 9174685
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
13,14-dihydro-15-keto Prostaglandin E1, 1 mg | sc-204999 | 1 mg | $94.00 | |||
13,14-dihydro-15-keto Prostaglandin E1, 5 mg | sc-204999A | 5 mg | $423.00 |