Date published: 2026-5-11

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13,14-dihydro-15-keto Prostaglandin A2 (CAS 74872-89-2)

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Alternate Names:
13,14-dihydro-15-keto PGA2; 9,15-dioxo-prosta-5Z,10-dien-1-oic acid
Application:
13,14-dihydro-15-keto Prostaglandin A2 is a product of 13,14-dihydro-15-keto PGE2 dehydration
CAS Number:
74872-89-2
Molecular Weight:
334.45
Molecular Formula:
C20H30O4
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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PGE2 is rapidly metabolized to 13,14-dihydro-15-keto PGE2, which is present in the plasma of humans and other mammals. 13,14-dihydro-15-keto PGA2 results from the non-enzymatic dehydration of 13,14-dihydro-15-keto PGE2, a process which is accelerated by the presence of albumin.1,2 Further decomposition of 13,14-dihydro-15-keto PGA2 by the intentional addition of base produces a stable marker of PGE2 biosynthesis: bicyclo PGE2.2


13,14-dihydro-15-keto Prostaglandin A2 (CAS 74872-89-2) References

  1. Identifying potential biomarkers and therapeutic targets for dogs with sepsis using metabolomics and lipidomics analyses.  |  Montague, B., et al. 2022. PLoS One. 17: e0271137. PMID: 35802586
  2. Metabolomic Analysis and MRM Verification of Coarse and Fine Skin Tissues of Liaoning Cashmere Goat.  |  Xu, Y., et al. 2022. Molecules. 27: PMID: 36080249
  3. Metabolomics Profiling of Age-Associated Metabolites in Malay Population.  |  Tan, JK., et al. 2023. Oxid Med Cell Longev. 2023: 4416410. PMID: 36785791
  4. Regulatory Effects of Ganoderma lucidum, Grifola frondosa, and American ginseng Extract Formulation on Gut Microbiota and Fecal Metabolomics in Mice.  |  Zhang, F., et al. 2023. Foods. 12: PMID: 37893697
  5. Integrated omics analysis reveals the alteration of gut microbiota and fecal metabolites in Cervus elaphus kansuensis.  |  Zhang, Z., et al. 2024. Appl Microbiol Biotechnol. 108: 125. PMID: 38229330
  6. Early fecal microbiota transplantation from high abdominal fat chickens affects recipient cecal microbiome and metabolism.  |  Song, J., et al. 2023. Front Microbiol. 14: 1332230. PMID: 38260901
  7. Untargeted metabolomics uncovers metabolic dysregulation and tissue sensitivity in ACE2 knockout mice.  |  Zhao, L., et al. 2024. Heliyon. 10: e27472. PMID: 38496880
  8. Characterizing the metabolome and microbiome at giant panda scent marking sites during the mating season.  |  Hou, J., et al. 2024. iScience. 27: 110051. PMID: 38904067
  9. The stability of 13,14-dihydro-15 keto-PGE2.  |  Fitzpatrick, FA., et al. 1980. Prostaglandins. 19: 917-31. PMID: 7384560
  10. Chemical instability of 15-keto-13,14-dihydro-PGE2: the reason for low assay reliability.  |  Granström, E., et al. 1980. Prostaglandins. 19: 933-57. PMID: 7384561

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

13,14-dihydro-15-keto Prostaglandin A2, 1 mg

sc-204997
1 mg
$84.00

13,14-dihydro-15-keto Prostaglandin A2, 5 mg

sc-204997A
5 mg
$379.00