Molecular structure of 12(S)-HHT, CAS Number: 54397-84-1
12(S)-HHT (CAS 54397-84-1)
Alternate Names:
12-HHTrE; 12S-hydroxy-5Z,8E,10E-heptadecatrienoic acid; 12(S)-Hydroxy-(5Z,8E,10E)-heptadecatrienoic acid
Application:
12(S)-HHT is an inhibitor of human platelet aggregation and stimulator of prostacyclin production
CAS Number:
54397-84-1
Molecular Weight:
280.40
Molecular Formula:
C17H28O3
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
This product is know to inhibit human platelet aggregation. It has been shown to stimulate the production of prostacyclin, an eicosanoid that exerts control over inflammation, immunity, and acts as a central nervous system messenger. 12(S)-HHT is metabolized by 15-hydroxyprostaglandin dehydrogenase to 12-KHT in human erythrocytes. It is also useful as a UV chromophore, and can be used in this manner to measure the metabolism of arachidonic acid via the cyclooxygenase pathway, and other cyclooxygenase activity.
12(S)-HHT (CAS 54397-84-1) References
- COX and LOX eicosanoids modulate platelet activation and procoagulation induced by two murine cancer cells. | Pasqualini, ME., et al. 2000. Prostaglandins Leukot Essent Fatty Acids. 63: 377-83. PMID: 11133175
- Lysophospholipids secreted by splenic macrophages induce chemotherapy resistance via interference with the DNA damage response. | Houthuijzen, JM., et al. 2014. Nat Commun. 5: 5275. PMID: 25387467
- The use of 12-hydroxyheptadecatrienoic acid (HHT) as an HPLC/spectrophotometric marker for cyclooxygenase pathway activity in resident rat peritoneal cells. | Sweeney, FJ., et al. 1987. Prostaglandins Leukot Med. 26: 171-7. PMID: 3033686
- Identification of 12-keto-5,8,10-heptadecatrienoic acid as an arachidonic acid metabolite produced by human HL-60 leukemia cells. | Agins, AP., et al. 1987. Biochem Pharmacol. 36: 1799-805. PMID: 3107571
- The platelet cyclooxygenase metabolite 12-L-hydroxy-5, 8, 10-hepta-decatrienoic acid (HHT) may modulate primary hemostasis by stimulating prostacyclin production. | Sadowitz, PD., et al. 1987. Prostaglandins. 34: 749-63. PMID: 3124219
- 12(S)-Hydroxy-5,8,10 (Z,E,E)-heptadecatrienoic acid (HHT) is preferentially metabolized to its 12-keto derivative by human erythrocytes in vitro. | Hecker, M. and Ullrich, V. 1988. Eicosanoids. 1: 19-25. PMID: 3272822
- Tumorigenic effect mediated by ROS/eicosanoids and their regulation on TP53 expression in a murine mammary gland adenocarcinoma. | Garay, MI., et al. 2021. Prostaglandins Other Lipid Mediat. 155: 106564. PMID: 34004336
- Products, kinetics, and substrate specificity of homogeneous thromboxane synthase from human platelets: development of a novel enzyme assay. | Hecker, M., et al. 1987. Arch Biochem Biophys. 254: 124-35. PMID: 3579292
- 12-L-hydroxy-5,8,10-heptadecatrienoic acid (HHT) is an excellent substrate for NAD+-dependent 15-hydroxyprostaglandin dehydrogenase. | Liu, Y., et al. 1985. Biochem Biophys Res Commun. 129: 268-74. PMID: 4004878
- The catalytic outcomes of the constitutive and the mitogen inducible isoforms of prostaglandin H2 synthase are markedly affected by glutathione and glutathione peroxidase(s). | Capdevila, JH., et al. 1995. Biochemistry. 34: 3325-37. PMID: 7880828
Inhibitor of:
EG435337.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
12(S)-HHT, 50 µg | sc-200969 | 50 µg | $325.00 | |||
12(S)-HHT, 250 µg | sc-200969A | 250 µg | $1632.00 |