Molecular structure of 12(S),20-DiHETE, CAS Number: 89614-44-8
12(S),20-DiHETE (CAS 89614-44-8)
See product citations (4)
Alternate Names:
12(S),20-diHETE
Application:
12(S),20-DiHETE is an arachidonic acid metabolite which engages in transcellular biosynthesis
CAS Number:
89614-44-8
Purity:
≥99%
Molecular Weight:
336.47
Molecular Formula:
C20H32O4
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
12(S),20-DiHETE, an arachidonic acid metabolite, has been demonstrated to be formed from 12-hydroxyeicosatetraenoic acid (12-HETE; sc-204982) during interaction between platelets and unstimulated neutrophils. This formation has been shown to be blocked by cytochrome P-450 inhibitors and leukotriene B4. Studies suggest that 12(S),20-DiHETE activates both cytoplasmic and lysosomal cholesteryl ester hydrolytic activity.
12(S),20-DiHETE (CAS 89614-44-8) References
- Distribution of tritium labeled 12(S) hydroxy-eicosatetraenoic acid (12-HETE) in the rat. | Clouet, P., et al. 1991. Prostaglandins. 42: 39-45. PMID: 1771238
- Platelet-neutrophil interactions. 12S,20- and 5S,12S-dihydroxyeicosapentaenoic acids: two novel neutrophil metabolites from platelet-derived 12S-hydroxyeicosapentaenoic acid. | von Schacky, C., et al. 1990. J Lipid Res. 31: 801-10. PMID: 2116491
- Platelet-neutrophil-smooth muscle cell interactions: lipoxygenase-derived mono- and dihydroxy acids activate cholesteryl ester hydrolysis by the cyclic AMP dependent protein kinase cascade. | Hajjar, DP., et al. 1989. Biochemistry. 28: 8885-91. PMID: 2557910
- Activity of dipyrone on intraplatelet arachidonic acid metabolism: an in vitro study. | Abbate, R., et al. 1989. Pharmacol Res. 21: 43-50. PMID: 2726664
- Deactivation of 12(S)-HETE through (ω-1)-hydroxylation and β-oxidation in alternatively activated macrophages. | Kriska, T., et al. 2018. J Lipid Res. 59: 615-624. PMID: 29472381
- Studies on the mechanism of omega-hydroxylation of platelet 12-hydroxyeicosatetraenoic acid (12-HETE) by unstimulated neutrophils. | Marcus, AJ., et al. 1987. J Clin Invest. 79: 179-87. PMID: 3025259
- 12S,20-dihydroxyicosatetraenoic acid: a new icosanoid synthesized by neutrophils from 12S-hydroxyicosatetraenoic acid produced by thrombin- or collagen-stimulated platelets. | Marcus, AJ., et al. 1984. Proc Natl Acad Sci U S A. 81: 903-7. PMID: 6583687
- Downregulation of human platelet reactivity by neutrophils. Participation of lipoxygenase derivatives and adhesive proteins. | Valles, J., et al. 1993. J Clin Invest. 92: 1357-65. PMID: 7690778
- Metabolism of arachidonic acid by canine polymorphonuclear leukocytes synthesis of lipoxygenase and omega-oxidized metabolites. | Rosolowsky, M., et al. 1996. Biochim Biophys Acta. 1300: 143-50. PMID: 8652640
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
12(S),20-DiHETE, 50 µg | sc-200412 | 50 µg | $419.00 |