12(R)-HETE CAS: 82337-46-0
MF: C20H32O3
MW: 320.5
A more potent inducer of human leukocyte chemokinesis and aggregation.

12(R)-HETE (CAS 82337-46-0)

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Application: 12(R)-HETE is a more potent inducer of human leukocyte chemokinesis and aggregation
CAS Number: 82337-46-0
Molecular Weight: 320.5
Molecular Formula: C20H32O3
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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12(R)-HETE is an arachidonic acid metabolite synthesized in the 12-lipoxygenase pathway in platelets and macrophages. Studies suggest that 12(R)-HETE is a better stimulator of leukocyte aggregation and enhances leukocyte chemokinesis better than its enantiomer 12(S)-HETE (sc-200942). In addition, 12(R)-HETE is an inhibitor of the Na+/K+ ATPase pump in corneal epithelium which could possibly have a role in regulating ocular transparency and aqueous human secretion.


References

1. Woollard, P.M., 1986. Biochem. Biophys. Res. Commun. 136: 169-176. PMID: 3707572
2. Evans, J.F., et al. 1987. Biochim. Biophys. Acta. 917: 406-410. PMID: 3026490
3. Schwartzman, M.L., et al. 1987. Proc. Natl. Acad. Sci. U.S.A. 84: 8125-8129. PMID: 2825178
4. Fruteau de Laclos, B., et al. 1987. Prostaglandins. 33: 315-337. PMID: 3107082
5. Masferrer, J.L., et al. 1990. Biochem. Pharmacol. 39: 1971-1974. PMID: 2162173

Formulation :
50 µg/ml in ethanol
Appearance :
Oil dissolved in ethanol
Physical State :
Liquid
Solubility :
DMSO and ethanol
Storage :
Store at -80° C
Boiling Point :
78° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
SMILES :
CCCCC/C=C\\C[[email protected]](/C=C/C=C\\C/C=C\\CCCC(=O)O)O

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