Molecular structure of 12(S)-hydroxy-16-Heptadecynoic Acid, CAS Number: 148019-74-3
12(S)-hydroxy-16-Heptadecynoic Acid (CAS 148019-74-3)
Application:
12(S)-hydroxy-16-Heptadecynoic Acid is a mechanism-based inhibitor of CYP ω hydroxylation
CAS Number:
148019-74-3
Molecular Weight:
282.4
Molecular Formula:
C17H30O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
Technical Information
Safety Information
SDS & Certificate of Analysis
12(S)-hydroxy-16-Heptadecynoic acid is a mechanism-based inhibitor of cytochrome P450 ω-hydroxylase (1). It inhibits prostaglandin ω-hydroxylase with a Ki value of 1.8 µM (1).
12(S)-hydroxy-16-Heptadecynoic Acid (CAS 148019-74-3) References
- Tumor-associated down-regulation of 15-lipoxygenase-1 is reversed by celecoxib in colorectal cancer. | Heslin, MJ., et al. 2005. Ann Surg. 241: 941-6; discussion 946-7. PMID: 15912043
- Antineoplastic Activity of Rhus trilobata Nutt. (Anacardiaceae) against Ovarian Cancer and Identification of Active Metabolites in This Pathology. | Varela-Rodríguez, L., et al. 2021. Plants (Basel). 10: PMID: 34685883
- Mechanism-based inhibitors of prostaglandin omega-hydroxylase: (R)- and (S)-12-hydroxy-16-heptadecynoic acid and 2,2-dimethyl-12-hydroxy-16-heptadecynoic acid. | Burger, A., et al. 1993. J Med Chem. 36: 1418-24. PMID: 8496909
- Metabolomic profiles of tropical Chlorella and Parachlorella species in response to physiological changes during exponential and stationary growth phase | Vejeysri Vello a b, Shivshankar Umashankar c d e, Siew-Moi Phang a b, Wan-Loy Chu f, Phaik-Eem Lim a b, Nazia Abdul Majid g, Kan-Ern Liew h i, Sanjay Swarup c d e, Fook-Tim Chew e. 2018. Algal Research. 35: 61-75.
Inhibitor of:
CYP.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
12(S)-hydroxy-16-Heptadecynoic Acid, 1 mg | sc-223157 | 1 mg | $116.00 | |||
12(S)-hydroxy-16-Heptadecynoic Acid, 5 mg | sc-223157A | 5 mg | $522.00 |