Molecular structure of 12-epi Leukotriene B4, CAS Number: 83709-73-3
12-epi Leukotriene B4 (CAS 83709-73-3)
Alternate Names:
12-epi LTB4
Application:
12-epi Leukotriene B4 is a leukotriene with less affinity than LTB4 at LTB4 receptors
CAS Number:
83709-73-3
Molecular Weight:
336.5
Molecular Formula:
C20H32O4
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
12-epi LTB4 is an isomer which would not be expected to occur in either non-enzymatic hydrolysis products, or in the enzymatic products of LTA4 hydrolase. Compared to LTB4, 12-epi LTB4 has significantly reduced affinity for the LTB4 receptor on human neutrophils (IC50 of 7.5 mM), and on guinea pig lung membranes with a (Ki of 4.7 mM), 12-epi LTB4 is an weak agonist at both the recombinant human P2Y7 and LTB4R2 (BLT1 and BLT2 receptors), requiring approximately 10 mM for full activation of the receptor.
12-epi Leukotriene B4 (CAS 83709-73-3) References
- Hydroxyeicosanoids bind to and activate the low affinity leukotriene B4 receptor, BLT2. | Yokomizo, T., et al. 2001. J Biol Chem. 276: 12454-9. PMID: 11278893
- Comparison of antagonist and agonist binding to the leukotriene B4 receptor intact human polymorphonuclear neutrophils (PMN). | Jackson, RH., et al. 1992. J Pharmacol Exp Ther. 262: 80-9. PMID: 1320692
- Leukotriene B4 enhances interleukin-6 (IL-6) production and IL-6 messenger RNA accumulation in human monocytes in vitro: transcriptional and posttranscriptional mechanisms. | Rola-Pleszczynski, M. and Stanková, J. 1992. Blood. 80: 1004-11. PMID: 1323342
- Characterization of a mouse second leukotriene B4 receptor, mBLT2: BLT2-dependent ERK activation and cell migration of primary mouse keratinocytes. | Iizuka, Y., et al. 2005. J Biol Chem. 280: 24816-23. PMID: 15866883
- Poxytrins, a class of oxygenated products from polyunsaturated fatty acids, potently inhibit blood platelet aggregation. | Chen, P., et al. 2011. FASEB J. 25: 382-8. PMID: 20833872
- Characterization of leukotriene B4 binding sites on guinea pig lung macrophages. | Cristol, JP., et al. 1988. J Pharmacol Exp Ther. 247: 1199-203. PMID: 2849666
- Effect of thiol-activated toxins (streptolysin O, alveolysin, and theta toxin) on the generation of leukotrienes and leukotriene-inducing and -metabolizing enzymes from human polymorphonuclear granulocytes. | Bremm, KD., et al. 1985. Infect Immun. 50: 844-51. PMID: 2866160
- The role of leukotriene-inducing and -metabolizing enzymes in inflammation. | König, W., et al. 1987. Int Arch Allergy Appl Immunol. 82: 526-31. PMID: 2883130
- Modulation of granulocyte functions by bacterial exotoxin and endotoxins. | Bremm, KD., et al. 1987. Immunology. 62: 363-71. PMID: 2889665
- Oxylipin profile of human low-density lipoprotein is dependent on its extent of oxidation. | Surendran, A., et al. 2019. Atherosclerosis. 288: 101-111. PMID: 31352271
- Synthesis of 11,12-leukotriene A4, 11S,12S-oxido-5Z,7E,9E,14Z-eicosatetraenoic acid, a novel leukotriene of the 12-lipoxygenase pathway. | Kitamura, S., et al. 1987. FEBS Lett. 213: 169-73. PMID: 3556576
- Electrospray-collision-induced dissociation mass spectrometry of mono-, di- and tri-hydroxylated lipoxygenase products, including leukotrienes of the B-series and lipoxins. | Griffiths, WJ., et al. 1996. Rapid Commun Mass Spectrom. 10: 183-96. PMID: 8616266
- Release of leukotriene A4 versus leukotriene B4 from human polymorphonuclear leukocytes. | Sala, A., et al. 1996. J Biol Chem. 271: 17944-8. PMID: 8663438
Activator of:
LTB4R2, and P2Y7.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
12-epi Leukotriene B4, 25 µg | sc-204980 | 25 µg | $176.00 | |||
12-epi Leukotriene B4, 50 µg | sc-204980A | 50 µg | $334.00 |