Molecular structure of 12-epi Leukotriene B3
12-epi Leukotriene B3
Molecular Weight:
338.5
Molecular Formula:
C20H34O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
An LTB isomer which would not be formed either by known enzymatic or non-enzymatic processes. The enzymatic hydrolysis of LTA leads to LTB, which is the corresponding 5(S),12(R)-dihydroxy acid containing a 6(Z),8(E),10(E) conjugated triene. Non-enzymatic hydrolysis of LTA produces neither of the material, but instead produces both the 12(S) and 12(R) isomers of LTB in which the triene component now contains a 6-trans double bond.1 12-epi (or 12(S)) LTB isomers which contain the natural 6-cis olefin are not produced either by enzymatic or by non-enzymatic processes. Further, 3-series LTs (derived from Mead acid) are only seen in essential fatty acid deficiency.
12-epi Leukotriene B3 References
- Essential fatty acid deficiency: probing the role of arachidonate in biology. | Lefkowith, JB. 1990. Adv Prostaglandin Thromboxane Leukot Res. 20: 224-31. PMID: 2144697
- Detection of the role of intestinal flora and tryptophan metabolism involved in antidepressant-like actions of crocetin based on a multi-omics approach. | Lin, S., et al. 2022. Psychopharmacology (Berl). 239: 3657-3677. PMID: 36169685
- Release of leukotriene A4 versus leukotriene B4 from human polymorphonuclear leukocytes. | Sala, A., et al. 1996. J Biol Chem. 271: 17944-8. PMID: 8663438
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
12-epi Leukotriene B3, 25 µg | sc-220587 | 25 µg | $379.00 | |||
12-epi Leukotriene B3, 50 µg | sc-220587A | 50 µg | $720.00 |