Molecular structure of 11Δ≤-13,14-dihydro-15-keto Prostaglandin F2α, CAS Number: 107615-77-0
11β-13,14-dihydro-15-keto Prostaglandin F2α (CAS 107615-77-0)
Application:
11β-13,14-dihydro-15-keto Prostaglandin F2α is a metabolite of PGD2 in the 15-hydroxy PGDH pathway
CAS Number:
107615-77-0
Molecular Weight:
354.5
Molecular Formula:
C20H34O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
11β-13,14-dihydro-15-keto Prostaglandin F2α (11β-13,14-dihydro-15-keto PGF2α) is a metabolite of Prostaglandin D2 (PGD2) in the 15-hydroxy PGDH pathway.1,2 Infusion or inhalation of tritiated PGD2 in normal males results in the appearance of peak levels of both 11β-PGF2α, as the immediate product, and 11β-13,14-dihydro-15-keto PGF2α in the plasma within 10 minutes.1 Homogenates of human lung metabolize PGD2 first to 11β-PGF2α and then to 11β-15-keto-PGF2α in the presence of NAD+, but no 11β-13,14-dihydro-15-keto PGF2α.2 Guinea pig liver and kidney homogenates metabolize PGD2 to 11β-13,14-dihydro-15-keto PGF2α, via 11β-PGF2α, in the presence of NAD+ and NADP+.2
11β-13,14-dihydro-15-keto Prostaglandin F2α (CAS 107615-77-0) References
- UPLC-MS/MS-Based Profiling of Eicosanoids in RAW264.7 Cells Treated with Lipopolysaccharide. | Lee, JW., et al. 2016. Int J Mol Sci. 17: 508. PMID: 27058537
- The metabolism of prostaglandin D2. Evidence for the sequential conversion by NADPH and NAD+ dependent pathways. | Robinson, C., et al. 1989. Biochem Pharmacol. 38: 3267-71. PMID: 2818626
- The metabolism of prostaglandin D2 after inhalation or intravenous infusion in normal men. | Robinson, C., et al. 1988. Biochim Biophys Acta. 963: 151-61. PMID: 3196723
- Combined metabolomic and proteomic analysis of sepsis related acute liver injury and its pathogenesis research. | Zhang, J., et al. 2024. Int Immunopharmacol. 130: 111666. PMID: 38412671
- Profile of uterine flush lipid mediators in cows with subclinical endometritis: pilot study. | Maehara, T., et al. 2024. J Vet Med Sci. 86: 518-523. PMID: 38522898
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
11β-13,14-dihydro-15-keto Prostaglandin F2α, 50 µg | sc-204976 | 50 µg | $50.00 | |||
11β-13,14-dihydro-15-keto Prostaglandin F2α, 100 µg | sc-204976A | 100 µg | $95.00 |