Molecular structure of 11-trans Leukotriene E4, CAS Number: 75715-88-7
11-trans Leukotriene E4 (CAS 75715-88-7)
Application:
11-trans Leukotriene E4 is an equipotent C-11 double bond isomer of LTE4
CAS Number:
75715-88-7
Molecular Weight:
439.6
Molecular Formula:
C23H37NO5S
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Leukotrienes comprise a family of endogenous metabolites of certain fatty acids and are related to thromboxanes and prostaglandins. They are potent eicosanoid lipid mediators that play numerous roles in inflammation, immunological functions and maintaining biological homeostasis. They possess a conjugated triene structure which gives them their name. They are generally isolated from leukocytes and primarily act through specific G protein-coupled receptors. The slow isomerization of the LTE4 C-11 double bond leads to the formation of 11-trans LTE4. 11-trans LTE4 has been shown to be equipotent to LTE4 in contracting guinea pig ileum.
11-trans Leukotriene E4 (CAS 75715-88-7) References
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- High-throughput lipidomic analysis of fatty acid derived eicosanoids and N-acylethanolamines. | Dumlao, DS., et al. 2011. Biochim Biophys Acta. 1811: 724-36. PMID: 21689782
- Metabolism of leukotriene E4 to 5-hydroxy-6-mercapto7,9-trans-11,14-cis-eicosatetraenoic acid by microfloral cysteine-conjugate beta-lyase and rat cecum contents. | Bernström, K., et al. 1989. Arch Biochem Biophys. 275: 531-9. PMID: 2556967
- Omega-oxidation of cysteine-containing leukotrienes by rat-liver microsomes. Isolation and characterization of omega-hydroxy and omega-carboxy metabolites of leukotriene E4 and N-acetylleukotriene E4. | Orning, L. 1987. Eur J Biochem. 170: 77-85. PMID: 2826163
- Metabolism and excretion of cysteinyl-leukotrienes. | Hammarström, S., et al. 1986. Adv Prostaglandin Thromboxane Leukot Res. 16: 383-96. PMID: 2949563
- Metabolism of leukotrienes. | Hammarström, S., et al. 1985. Mol Cell Biochem. 69: 7-16. PMID: 3001504
- Metabolism of leukotriene C3 in the guinea pig. Identification of metabolites formed by lung, liver, and kidney. | Hammarström, S. 1981. J Biol Chem. 256: 9573-8. PMID: 6116705
- Metabolism of leukotriene D by porcine kidney. | Bernström, K. and Hammarström, S. 1981. J Biol Chem. 256: 9579-82. PMID: 6895224
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
11-trans Leukotriene E4, 25 µg | sc-204973 | 25 µg | $176.00 | |||
11-trans Leukotriene E4, 50 µg | sc-204973A | 50 µg | $334.00 |