Date published: 2025-11-6

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11(R)-HETE (CAS 73347-43-0)

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Application:
11(R)-HETE is a naturally occurring fatty acid whose biological activity affects maturation and regeneration
CAS Number:
73347-43-0
Molecular Weight:
320.5
Molecular Formula:
C20H32O3
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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11(R)-HETE, designated by the CAS number 73347-43-0, is a specific enantiomer of 11-hydroxyeicosatetraenoic acid, a metabolite arising from the lipoxygenase-mediated oxidation of arachidonic acid. This particular isomer, characterized by the R configuration of the hydroxyl group at the eleventh carbon, plays a significant role in cellular signaling processes. The action of 11(R)-HETE in research focuses on its ability to modulate various intracellular functions such as the regulation of inflammatory mediator production, influencing gene expression, and altering cellular receptor activity. This hydroxy fatty acid is particularly valuable in the study of lipid-mediated signaling pathways that are fundamental to understanding cellular responses to environmental changes and stressors. By interacting with specific proteins and receptors within the cell, 11(R)-HETE contributes to the regulation of cellular processes that maintain homeostasis and respond to external stimuli. Researchers utilize this compound to explore how lipid signaling impacts cell behavior, further elucidating the complex network of biochemical pathways that control cell function. These studies provide crucial insights into the dynamics of lipid mediators and their regulatory roles, enhancing our understanding of cellular mechanisms at the molecular level, which is pivotal for the broader field of cell biology and biochemistry.


11(R)-HETE (CAS 73347-43-0) References

  1. Cyclooxygenase-2-mediated DNA damage.  |  Lee, SH., et al. 2005. J Biol Chem. 280: 28337-46. PMID: 15964853
  2. Cyclooxygenase-2-mediated metabolism of arachidonic acid to 15-oxo-eicosatetraenoic acid by rat intestinal epithelial cells.  |  Lee, SH., et al. 2007. Chem Res Toxicol. 20: 1665-75. PMID: 17910482
  3. 11-Oxoeicosatetraenoic acid is a cyclooxygenase-2/15-hydroxyprostaglandin dehydrogenase-derived antiproliferative eicosanoid.  |  Liu, X., et al. 2011. Chem Res Toxicol. 24: 2227-36. PMID: 21916491
  4. Mechanism of biosynthesis of 11R-and 12R-hydroxyeicosatetraenoic acids by eggs of the sea urchin Strongylocentrotus purpuratus.  |  Hawkins, DJ. and Brash, AR. 1989. FEBS Lett. 247: 9-12. PMID: 2495992
  5. Eggs of the sea urchin, Strongylocentrotus purpuratus, contain a prominent (11R) and (12R) lipoxygenase activity.  |  Hawkins, DJ. and Brash, AR. 1987. J Biol Chem. 262: 7629-34. PMID: 3108255
  6. Enantioselective ultra-high performance liquid chromatography-tandem mass spectrometry method based on sub-2µm particle polysaccharide column for chiral separation of oxylipins and its application for the analysis of autoxidized fatty acids and platelet releasates.  |  Cebo, M., et al. 2020. J Chromatogr A. 1624: 461206. PMID: 32540064
  7. Changes of tear lipid mediators after eyelid warming or thermopulsation treatment for meibomian gland dysfunction.  |  Ambaw, YA., et al. 2020. Prostaglandins Other Lipid Mediat. 151: 106474. PMID: 32783924
  8. Polyunsaturated-fatty-acid oxidation in Hydra: regioselectivity, substrate-dependent enantioselectivity and possible biological role.  |  Di Marzo, V., et al. 1994. Biochem J. 300 (Pt 2): 501-7. PMID: 8002956
  9. Synthesis of hydroxyeicosatetraenoic (HETEs) and epoxyeicosatrienoic acids (EETs) by cultured bovine coronary artery endothelial cells.  |  Rosolowsky, M. and Campbell, WB. 1996. Biochim Biophys Acta. 1299: 267-77. PMID: 8555273
  10. Analysis of hydroperoxide-induced tyrosyl radicals and lipoxygenase activity in aspirin-treated human prostaglandin H synthase-2.  |  Xiao, G., et al. 1997. Biochemistry. 36: 1836-45. PMID: 9048568

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

11(R)-HETE, 25 µg

sc-204974
25 µg
$140.00

11(R)-HETE, 50 µg

sc-204974A
50 µg
$266.00