11-keto Fluprostenol (CAS 62145-07-7)

11-keto Fluprostenol is a modified analog of prostaglandin D2 (PGD2) designed to enhance its potency and prolong its half-life. It acts primarily through the FP receptor and exhibits moderate binding to the CRTH2/DP2 receptor. Oxidation of fluprostenol at C-11 yields 11-keto Fluprostenol. This synthetic, non-steroidal prostaglandin analogue is extensively employed in laboratory research to investigate the impact of prostaglandins on human physiology and biochemistry. The prominent role of 11-keto Fluprostenol lies in its ability to activate the prostaglandin E2 (PGE2) receptor, making it an influential tool in numerous scientific studies. These studies delve into the effects of PGE2 and its downstream signaling pathways on various biological processes, including inflammation, cell migration, cardiovascular function, and nervous system regulation. Additionally, 11-keto Fluprostenol has been instrumental in examining the impact of PGE2 on gene expression, cell proliferation, adhesion, cytokine production, as well as cell survival and death. By binding to the prostaglandin E2 receptor (EP2), 11-keto Fluprostenol triggers the activation of multiple downstream signaling pathways. These include the mitogen-activated protein kinase (MAPK) cascade, the phosphoinositide 3-kinase (PI3K) cascade, and the nuclear factor-kappa B (NF-κB) cascade. Consequently, these signaling pathways orchestrate the activation of various genes involved in inflammation, cell migration, cell proliferation, adhesion, and cytokine production.