Molecular structure of 11-deoxy Prostaglandin E1, CAS Number: 37786-00-8
11-deoxy Prostaglandin E1 (CAS 37786-00-8)
Alternate Names:
11-deoxy PGE1; 9-oxo-15S-hydroxy-prost-13E-en-1-oic acid
Application:
11-deoxy Prostaglandin E1 is an agonist of EP2, EP3, and EP4
CAS Number:
37786-00-8
Purity:
≥96%
Molecular Weight:
338.48
Molecular Formula:
C20H34O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
11-deoxy Prostaglandin E1 (11-deoxy PGE1) is a synthetic analog of PGE1 (sc-201223). Early reports show that it is a selective agonist for EP2 (the EP2 receptor) but effective at much higher concentrations than PGE2. However, later studies show that it is a non-selective agonist of EP receptors and stimulates cAMP release in Jurkat cells with an EC50 of 0.25 muM. 11-deoxy Prostaglandin E1 exhibits selectively for the mouse EP3 (EP3 receptor) and is essentially equipotent to PGE1 at this receptor subtype. The Ki values for binding to the mouse EP1, EP2, EP3, and EP4 (EP1, EP2, EP3, and EP4 receptors) are 600, 45, 1.1, and 23 nM, respectively.
11-deoxy Prostaglandin E1 (CAS 37786-00-8) References
- The role of PGE2 and EP receptors on lung's immune and structural cells; possibilities for future asthma therapy. | Cebulla, D., et al. 2023. Pharmacol Ther. 241: 108313. PMID: 36427569
Activator of:
EP2, EP3, and EP4.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
11-deoxy Prostaglandin E1, 500 µg | sc-223150 | 500 µg | $49.00 | |||
11-deoxy Prostaglandin E1, 1 mg | sc-223150A | 1 mg | $70.00 |