Date published: 2025-11-30

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11-dehydro Thromboxane B2-d4 (CAS 1240398-15-5)

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Alternate Names:
11-keto TXB2-d4
Application:
11-dehydro Thromboxane B2-d4 is used as an internal standard for the quantification of 11-dehydro TXB2 by GC- or LC-mass spectrometry
CAS Number:
1240398-15-5
Molecular Weight:
372.50
Molecular Formula:
C20H28D4O6
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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11-dehydro Thromboxane B2-d4 contains 4 deuterium atoms at the 3, 3′, 4, and 4′ positions and is intended for use as an internal standard for the quantification of 11-dehydro TXB2 by GC- or LC-mass spectrometry. TXB2 is released in substantial quantities from aggregating platelets and metabolized during circulation to 11-dehydro TXB2 and 2,3-dinor TXB2. 11-dehydro TXB2 is one of the main plasma metabolites of TXB2 and can be used as a marker for n vivo TXA2 synthesis. 11-dehydro Thromboxane B2-d4 (11-dehydro-TxB2-d4) is a reliable and cost-effective analogue of 11-dehydro Thromboxane B2 (11-dehydro-TxB2), which is a metabolite of thromboxane B2 (TxB2). Due to its stability and lack of radioactivity, 11-dehydro-TxB2-d4 finds utility in various scientific research endeavors. It is particularly valuable in studying the involvement of thromboxane A2 (TxA2) in diverse biological processes.


11-dehydro Thromboxane B2-d4 (CAS 1240398-15-5) References

  1. Integrated analysis of COX-2 and iNOS derived inflammatory mediators in LPS-stimulated RAW macrophages pre-exposed to Echium plantagineum L. bee pollen extract.  |  Moita, E., et al. 2013. PLoS One. 8: e59131. PMID: 23520554
  2. 11-dehydro thromboxane B2 levels after percutaneous transluminal angioplasty in patients with peripheral arterial occlusive disease during a one year follow-up period.  |  Maga, P., et al. 2016. J Physiol Pharmacol. 67: 377-83. PMID: 27511998
  3. Profiling of bioactive lipids in different dendritic cell subsets using an improved multiplex quantitative LC-MS/MS method.  |  Ohba, M., et al. 2018. Biochem Biophys Res Commun. 504: 562-568. PMID: 29890138
  4. Simultaneous determination of PUFA-derived pro-resolving metabolites and pathway markers using chiral chromatography and tandem mass spectrometry.  |  Toewe, A., et al. 2018. Anal Chim Acta. 1031: 185-194. PMID: 30119738
  5. Treatment with PCSK9 Inhibitors in Patients with Familial Hypercholesterolemia Lowers Plasma Levels of Platelet-Activating Factor and Its Precursors: A Combined Metabolomic and Lipidomic Approach.  |  Di Minno, A., et al. 2021. Biomedicines. 9: PMID: 34440277

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

11-dehydro Thromboxane B2-d4, 25 µg

sc-220574
25 µg
$355.00

11-dehydro Thromboxane B2-d4, 50 µg

sc-220574A
50 µg
$551.00

11-dehydro Thromboxane B2-d4, 100 µg

sc-220574B
100 µg
$673.00

11-dehydro Thromboxane B2-d4, 500 µg

sc-220574C
500 µg
$3060.00