Molecular structure of 10074-G5, CAS Number: 413611-93-5
10074-G5 (CAS 413611-93-5)
See product citations (3)
Alternate Names:
Biphenyl-2-yl-(7-nitrobenzo[1,2,5]oxadiazol-4-yl)amine; N-2-Biphenylyl-7-nitro-2,1,3-benzoxadiazol-4-amine
Application:
10074-G5 is an inhibitor of c-Myc-Max interaction
CAS Number:
413611-93-5
Purity:
>98%
Molecular Weight:
332.31
Molecular Formula:
C18H12N4O3
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
A c-Myc Max interaction inhibitor. The c-Myc oncoprotein and its partner Max are intrinsically disordered (ID) monomers that undergo coupled folding and binding upon heterodimerization. 10074-G5, similarly to 10058-F4, specifically inhibits this interaction by binding to c-Myc, thus preventing C-Myc specific DNA binding and target genes regulation. 10074-G5 (2.8 microM) is slightly more potent that 10058-F4 (5.2 microM) most likely due to the fact that 10074-G5 binds to a different region of C-Myc than 10054-F4. Thus, the compound may become desirable for probing different interactions.
10074-G5 (CAS 413611-93-5) References
Follis, A.V., et al., Structural rationale for the coupled binding and unfolding of the c-Myc oncoprotein by small molecules. Chem. Biol. 15, 1149-1155, (2008); Yin, X., et al., Low molecular weight inhibitors of Myc-Max interaction and function. Oncogene 22, 6151-6159, (2003)Inhibitor of:
B-Myc, c-Myc, ISY1, Mnt, Mxi1, N-Myc, and S-Myc.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
10074-G5, 5 mg | sc-213578 | 5 mg | $82.00 | |||
10074-G5, 10 mg | sc-213578B | 10 mg | $154.00 | |||
10074-G5, 25 mg | sc-213578A | 25 mg | $330.00 | |||
10074-G5, 100 mg | sc-213578C | 100 mg | $982.00 | |||
10074-G5, 1 g | sc-213578D | 1 g | $2045.00 |