Molecular structure of 10058-F4, CAS Number: 403811-55-2
10058-F4 (CAS 403811-55-2)
See product citations (9)
Alternate Names:
5-[(4-Ethylphenyl)methylene]-2-thioxo-4-thiazolidinone
Application:
10058-F4 is a c-Myc inhibitor and apoptosis inducer
CAS Number:
403811-55-2
Purity:
≥95%
Molecular Weight:
249.35
Molecular Formula:
C12H11NOS2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
10058-F4 is a c-Myc inhibitor that prevents c-Myc/Max dimerization. c-Myc is a proto-oncogene that plays an important role in cell proliferation, differentiation, and apoptosis. 10058-F4 may act to arrest cell growth at G0/G1 phase. Experiments show that extended exposure to 10058-F4 causes apoptosis via upregulation of Bax, expression of cytoplasmic Cytochrome C, down-regulation of Bcl-2, and cleavage of caspase-3,-7, and -9. This compound has been found to also upregulate cyclin-dependent kinase inhibitors, p21 and p27.
10058-F4 (CAS 403811-55-2) References
- A small-molecule c-Myc inhibitor, 10058-F4, induces cell-cycle arrest, apoptosis, and myeloid differentiation of human acute myeloid leukemia. | Huang, MJ., et al. 2006. Exp Hematol. 34: 1480-9. PMID: 17046567
- Small-molecule c-Myc inhibitor, 10058-F4, inhibits proliferation, downregulates human telomerase reverse transcriptase and enhances chemosensitivity in human hepatocellular carcinoma cells. | Lin, CP., et al. 2007. Anticancer Drugs. 18: 161-70. PMID: 17159602
- Efficacy, pharmacokinetics, tisssue distribution, and metabolism of the Myc-Max disruptor, 10058-F4 [Z,E]-5-[4-ethylbenzylidine]-2-thioxothiazolidin-4-one, in mice. | Guo, J., et al. 2009. Cancer Chemother Pharmacol. 63: 615-25. PMID: 18509642
- 10058-F4, a c-Myc inhibitor, markedly increases valproic acid-induced cell death in Jurkat and CCRF-CEM T-lymphoblastic leukemia cells. | Mu, Q., et al. 2014. Oncol Lett. 8: 1355-1359. PMID: 25120723
- Inhibition of c-Myc by 10058-F4 induces growth arrest and chemosensitivity in pancreatic ductal adenocarcinoma. | Zhang, M., et al. 2015. Biomed Pharmacother. 73: 123-8. PMID: 26211592
- C‑Myc inhibitor 10058‑F4 increases the efficacy of dexamethasone on acute lymphoblastic leukaemia cells. | Lv, M., et al. 2018. Mol Med Rep. 18: 421-428. PMID: 29749488
- Suppression of c-Myc using 10058-F4 exerts caspase-3-dependent apoptosis and intensifies the antileukemic effect of vincristine in pre-B acute lymphoblastic leukemia cells. | Sheikh-Zeineddini, N., et al. 2019. J Cell Biochem. 120: 14004-14016. PMID: 30957273
- ACSL4 promotes hepatocellular carcinoma progression via c-Myc stability mediated by ERK/FBW7/c-Myc axis. | Chen, J., et al. 2020. Oncogenesis. 9: 42. PMID: 32350243
- c-Myc Inhibition Using 10058-F4 Increased the Sensitivity of Acute Promyelocytic Leukemia Cells to Arsenic Trioxide Via Blunting PI3K/NF-κB Axis. | Sayyadi, M., et al. 2020. Arch Med Res. 51: 636-644. PMID: 32553459
- NF-κB-dependent Mechanism of Action of c-Myc Inhibitor 10058-F4: Highlighting a Promising Effect of c-Myc Inhibition in Leukemia Cells, Irrespective of p53 Status. | Sayyadi, M., et al. 2020. Iran J Pharm Res. 19: 153-165. PMID: 32922477
- Intestinal MYC modulates obesity-related metabolic dysfunction. | Luo, Y., et al. 2021. Nat Metab. 3: 923-939. PMID: 34211180
- Inhibition of c-Myc using 10058-F4 induces anti-tumor effects in ovarian cancer cells via regulation of FOXO target genes. | Ghaffarnia, R., et al. 2021. Eur J Pharmacol. 908: 174345. PMID: 34270986
- A novel Cereblon E3 ligase modulator with antitumor activity in gastrointestinal cancer. | Lier, S., et al. 2022. Bioorg Chem. 119: 105505. PMID: 34838332
- Tumorigenic circulating tumor cells from xenograft mouse models of non-metastatic NSCLC patients reveal distinct single cell heterogeneity and drug responses. | Suvilesh, KN., et al. 2022. Mol Cancer. 21: 73. PMID: 35279152
Inhibitor of:
B-Myb, B-Myc, c-Myb, c-Myc, ISY1, L-Myc, Max, Myc, Myc1, MYCBP, and S-Myc.Activator of:
Miz-1, and Mxi1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
10058-F4, 5 mg | sc-213577 | 5 mg | $81.00 | |||
10058-F4, 10 mg | sc-213577B | 10 mg | $134.00 | |||
10058-F4, 25 mg | sc-213577A | 25 mg | $241.00 | |||
10058-F4, 50 mg | sc-213577C | 50 mg | $426.00 |