Molecular structure of 10-Desacetyl Paclitaxel, CAS Number: 78432-77-6
10-Desacetyl Paclitaxel (CAS 78432-77-6)
See product citations (1)
Alternate Names:
10-Deacetylpaclitaxel; 10-Deacetyltaxol; 10-Desacetyltaxol; 10-O-Deacetyltaxol
Application:
10-Desacetyl Paclitaxel is a semi-synthetic precursor of Paclitaxel
CAS Number:
78432-77-6
Molecular Weight:
811.87
Molecular Formula:
C45H49NO13
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
10-Desacetyl Paclitaxel is a compound that functions as a microtubule stabilizer. 10-Desacetyl Paclitaxel binds to tubulin, promoting the assembly of microtubules and inhibiting their disassembly, thereby disrupting the dynamic equilibrium of microtubule growth. This interference with microtubule dynamics ultimately leads to cell cycle arrest and apoptosis in rapidly dividing cells. 10-Desacetyl Paclitaxel′s mechanism of action involves its ability to bind to beta-tubulin subunits, stabilizing microtubules and disrupting the normal function of the cytoskeleton.
10-Desacetyl Paclitaxel (CAS 78432-77-6) References
- P-glycoprotein and cytochrome P450 3A act together in restricting the oral bioavailability of paclitaxel. | Hendrikx, JJ., et al. 2013. Int J Cancer. 132: 2439-47. PMID: 23090875
- Comparative metabolomic analysis reveals the variations in taxoids and flavonoids among three Taxus species. | Zhou, T., et al. 2019. BMC Plant Biol. 19: 529. PMID: 31783790
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
10-Desacetyl Paclitaxel, 5 mg | sc-206268 | 5 mg | $393.00 |