Molecular structure of 10-DEBC hydrochloride, CAS Number: 201788-90-1
10-DEBC hydrochloride (CAS 201788-90-1)
See product citations (12)
Alternate Names:
Akt Inhibitor X; 10-[4′-(N,N-Diethylamino)butyl]-2-ch lorophenoxazine hydrochloride
Application:
10-DEBC hydrochloride is a selective inhibitor of Akt/PKB
CAS Number:
201788-90-1
Purity:
≥99 %
Molecular Weight:
381.34
Molecular Formula:
C20H25ClN2O•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
Available in US only.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Selective inhibitor of Akt/PKB. Inhibits IGF-1-stimulated phosphorylation and activation of Akt (complete inhibition at 2.5 μM), suppressing downstream activation of mTOR, p70 S6 kinase and S6 ribosomal protein. Shows no activity at PDK1, SGK1 or PI 3-kinase. Inhibits cell growth (IC50 ~ 2-6 μM) and induces apoptosis in rhabdomyosarcoma cells.
10-DEBC hydrochloride (CAS 201788-90-1) References
- Synthesis and chemical characterization of N-substituted phenoxazines directed toward reversing vinca alkaloid resistance in multidrug-resistant cancer cells. | Thimmaiah, KN., et al. 1992. J Med Chem. 35: 3358-64. PMID: 1527786
- Identification of N10-substituted phenoxazines as potent and specific inhibitors of Akt signaling. | Thimmaiah, KN., et al. 2005. J Biol Chem. 280: 31924-35. PMID: 16009706
- Metformin reduces cisplatin-mediated apoptotic death of cancer cells through AMPK-independent activation of Akt. | Janjetovic, K., et al. 2011. Eur J Pharmacol. 651: 41-50. PMID: 21114978
- Inhibition of AMPK-dependent autophagy enhances in vitro antiglioma effect of simvastatin. | Misirkic, M., et al. 2012. Pharmacol Res. 65: 111-9. PMID: 21871960
- Coordinated time-dependent modulation of AMPK/Akt/mTOR signaling and autophagy controls osteogenic differentiation of human mesenchymal stem cells. | Pantovic, A., et al. 2013. Bone. 52: 524-31. PMID: 23111315
- Honokiol and Magnolol Inhibit CXCL10 and CXCL11 Production in IL-27-Stimulated Human Oral Epithelial Cells. | Hosokawa, Y., et al. 2018. Inflammation. 41: 2110-2115. PMID: 30039429
- Carnosic Acid Inhibits CXCR3 Ligands Production in IL-27-Stimulated Human Oral Epithelial Cells. | Hosokawa, I., et al. 2019. Inflammation. 42: 1311-1316. PMID: 30820808
- Fibroblast Growth Factor 21 Attenuates Diabetes-Induced Renal Fibrosis by Negatively Regulating TGF-β-p53-Smad2/3-Mediated Epithelial-to-Mesenchymal Transition via Activation of AKT. | Lin, S., et al. 2020. Diabetes Metab J. 44: 158-172. PMID: 31701691
- 10-DEBC Hydrochloride as a Promising New Agent against Infection of Mycobacterium abscessus. | Lee, DG., et al. 2022. Int J Mol Sci. 23: PMID: 35054777
- Pharmacological Akt and JNK Kinase Inhibitors 10-DEBC and SP600125 Potentiate Anti-Glioblastoma Effect of Menadione and Ascorbic Acid Combination in Human U251 Glioblastoma Cells. | Despotović, A., et al. 2023. Biomedicines. 11: PMID: 37893026
Inhibitor of:
Akt.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
10-DEBC hydrochloride, 10 mg | sc-203459 | 10 mg | $223.00 | |||
| US: Only available in the US | ||||||
10-DEBC hydrochloride, 50 mg | sc-203459A | 50 mg | $570.00 | |||
| US: Only available in the US | ||||||