Date published: 2026-3-29

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1-Stearoyl-sn-glycero-3-phosphocholine (CAS 19420-57-6)

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Alternate Names:
1-Stearoyl-2-lyso-sn-glycero-3-PC; stearoyl alpha-lysolecithin
Application:
1-Stearoyl-sn-glycero-3-phosphocholine is a chemical used in lipid metabolism studies
CAS Number:
19420-57-6
Molecular Weight:
523.68
Molecular Formula:
C26H54NO7P
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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1-Stearoyl-sn-glycero-3-phosphocholine is a synthetic phospholipid used extensively in membrane biophysics and biochemistry research. It features a stearoyl fatty acid chain, a saturated long-chain fatty acid, attached to the sn-1 position of a glycerol backbone, which is connected to a phosphocholine group. This composition makes it a critical component in studies of lipid bilayers and liposome formulation, providing insights into membrane fluidity, phase behavior, and lipid-protein interactions. Its phosphocholine headgroup is particularly relevant in understanding the role of choline-containing lipids in cellular signaling and membrane structure stability. Research using 1-Stearoyl-sn-glycero-3-phosphocholine helps explain how changes in membrane lipid composition can affect cellular processes such as vesicle trafficking, signal transduction, and receptor function. This phospholipid is also utilized to model the effects of saturated fatty acids on the physical properties of membranes, offering a deeper understanding of membrane dynamics crucial for basic cellular functions.


1-Stearoyl-sn-glycero-3-phosphocholine (CAS 19420-57-6) References

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  2. Morphological effect of lipid carriers on permeation of lidocaine hydrochloride through lipid membranes.  |  Shim, J., et al. 2010. Int J Pharm. 388: 251-6. PMID: 20060459
  3. X-ray grazing incidence diffraction and Langmuir monolayer studies of the interaction of beta-cyclodextrin with model lipid membranes.  |  Flasiński, M., et al. 2010. J Colloid Interface Sci. 348: 511-21. PMID: 20493495
  4. Plant-derived phenolics inhibit the accrual of structurally characterised protein and lipid oxidative modifications.  |  Soler-Cantero, A., et al. 2012. PLoS One. 7: e43308. PMID: 22952663
  5. Inactivation of HDAC3 and STAT3 is critically involved in 1-stearoyl-sn-glycero-3-phosphocholine-induced apoptosis in chronic myelogenous leukemia K562 cells.  |  Jung, JH., et al. 2013. Cell Biochem Biophys. 67: 1379-89. PMID: 23729004
  6. Novel temperature-triggered liposome with high stability: formulation, in vitro evaluation, and in vivo study combined with high-intensity focused ultrasound (HIFU).  |  Park, SM., et al. 2013. J Control Release. 170: 373-9. PMID: 23770213
  7. Laser Desorption/Ionization Mass Spectrometry (LDI-MS) of Lipids with Iron Oxide Nanoparticle-Coated Targets.  |  Kusano, M., et al. 2014. Mass Spectrom (Tokyo). 3: A0026. PMID: 24860715
  8. Lysophosphatidylcholine acts in the constitutive immune defence against American foulbrood in adult honeybees.  |  Riessberger-Gallé, U., et al. 2016. Sci Rep. 6: 30699. PMID: 27480379
  9. Continuous gradient temperature Raman spectroscopy from -100 to 40°C yields new molecular models of arachidonic acid and 2-Arachidonoyl-1-stearoyl-sn-glycero-3-phosphocholine.  |  Broadhurst, CL., et al. 2017. Prostaglandins Leukot Essent Fatty Acids. 127: 6-15. PMID: 29156157
  10. A four parameter optimization and troubleshooting of a RPLC - charged aerosol detection stability indicating method for determination of S-lysophosphatidylcholines in a phospholipid formulation.  |  Tam, J., et al. 2018. J Pharm Biomed Anal. 155: 288-297. PMID: 29677679

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

1-Stearoyl-sn-glycero-3-phosphocholine, 100 mg

sc-208698
100 mg
$275.00

1-Stearoyl-sn-glycero-3-phosphocholine, 1 g

sc-208698A
1 g
$800.00