1-Stearoyl-2-Arachidonoyl-sn-Glycerol-d8 (CAS 65914-84-3 (unlabeled))
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SAG-d8 contains eight deuterium atoms at the 5, 6, 8, 9, 11, 12, 14, and 15 positions. Intended for use as an internal standard for the quantification of SAG by GC- or LC-mass spectrometry. Many protein kinase C (PKC) isoforms require activation via second messengers including Ca2+, diacylglycerol (DAG), and/or a phospholipid in order to phosphorylate target proteins, initiating a variety of important signaling cascades.1 1 It is a DAG that contains the ω-6 polyunsaturated fatty acid arachidonic acid in the sn-2 position and stearic acid in the sn-1 position of the glycerol backbone. Can potently activate PKCα, ε, and δ at nM concentrations.2 Independent of PKC signaling, SAG competitively binds to the Ras activator RasGRP with a Ki value of 4.49 µM in Jurkat T-cells.3
1-Stearoyl-2-Arachidonoyl-sn-Glycerol-d8 (CAS 65914-84-3 (unlabeled)) References
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- Diacylglycerols containing Omega 3 and Omega 6 fatty acids bind to RasGRP and modulate MAP kinase activation. | Madani, S., et al. 2004. J Biol Chem. 279: 1176-83. PMID: 14583629
- Repeated homotypic stress elevates 2-arachidonoylglycerol levels and enhances short-term endocannabinoid signaling at inhibitory synapses in basolateral amygdala. | Patel, S., et al. 2009. Neuropsychopharmacology. 34: 2699-709. PMID: 19675536
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- Reprogramming fatty acyl specificity of lipid kinases via C1 domain engineering. | Ware, TB., et al. 2020. Nat Chem Biol. 16: 170-178. PMID: 31932721
- Diacylglycerol lipase alpha in astrocytes is involved in maternal care and affective behaviors. | Schuele, LL., et al. 2021. Glia. 69: 377-391. PMID: 32876968
- AP-4-mediated axonal transport controls endocannabinoid production in neurons. | Davies, AK., et al. 2022. Nat Commun. 13: 1058. PMID: 35217685
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Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
1-Stearoyl-2-Arachidonoyl-sn-Glycerol-d8, 100 µg | sc-220503 | 100 µg | $70.00 | |||
1-Stearoyl-2-Arachidonoyl-sn-Glycerol-d8, 500 µg | sc-220503A | 500 µg | $305.00 | |||
1-Stearoyl-2-Arachidonoyl-sn-Glycerol-d8, 1 mg | sc-220503B | 1 mg | $540.00 |